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Experimental Abilation
destroying part of the brain and evaluating the animals subsaequent behavior; the functions can no longer be preformed in the region that abilation occured
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Lesion
a wound or injury; lesion=experimental abilation
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____ within the brain preform ____, not behaviors
circuts, functions
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can one brain region or neural circut souley be responsible for behavior
no
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Excitotoxic lesion
a method of producing brain lesions; intracerebral injection of an excitatory amino acid, such as kainic acid
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Sham lesion
a method of produciong brain lesions; placebo procedure that duplicates all procedures of a brain lesion except for the step that actually causes the damage to the brain
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Stereotaxic surgury
Brain surgury using a stereotaxic apparatus to position an electrode in a specified position of the brain
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Stereotaxic atlas
a collection of drawings of sections of the brain of a particular animal with measurements that provide coordinates for the stereotaxic surgury
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hostological methods as it pertains to brain lesions
they often miss the mark
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scanning electron microscope
provides 3d information about the shape of the surface of a small object
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Anterograde labeling method
a histological method that labels the axon and terminal buttons or neurons whose cell bodies are located in a particular region
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PHA-L
a protein derived from kidney beans and used as an anterograde tracer; taken up by dendrites and cell bodies and carried to the ends of the axons
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Immunocytochemical method
they take advantage of the immune reaction; a histological method; antibodies bond with a dye molecule to indicate the presense of particular proteins of peptides
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retrograde labeling method
a histological method that labels cell bodies that give rise to the terminal buttons that form synapses with cells in a particular region
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flurogold
retrograde labeling dye that is taken up by the terminal buttons and then carried back to the cell bodies
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Brain functions involve activity of circuts of _____; thus, diffrent perceptiona and behavioral rsponses involve diffrent ____ __ _______ in the brain
neurons, patterns of activity
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EEG
an electrical brain potential recorded by placing electrodes on the scalp; record electrical patterns of electrical activity
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MEG
a procedure that detects groups of synchronously activated neurons by means of the magnetic field induced by their electrical activity; ueses an array od SQUIDs
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Microelectrode
A very fine electrode, generally used to record activity of individual neurons
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Single-unit recording
recording of the eectrical activity of a single neuron
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macroelectrode
an electrode used to record the electrical activity of large numbers of neurons in a particular region of the brain
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Functional imaging
a computerized method of detecting metabolic or chemical changes in particular regions of the brain
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PET scan
a functional imaging method; reveals the localization of radioactive tracer in a living brain
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fMRI
permits the measurement of regional metabolism in the brain
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MRI
a technique whereby the interior of the body can be accurately imaged; involves the interaction between radio waves and a strong magnetic field
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CT scan
a device tha employs ba computer to analize data obtained by a scanning beam of x-rays to produce a two-dimensional picture of a "slicde" trhough the body
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DTI
an imaging method that uses a modified MRI scanner to reveal bundles of myelinated axons in the living human brain
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Stimulating neural activity: Chemical stimulation
usually acomplished by injecting a small amount of exciatory amino acod, such as kainic acid or glutamic acid into the bain; stimulates neurons near the tip of the cannula, not axons passing through region
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TMS
stimulation of the cerebral cortex by means of magnetic magnetic fields produced by passing pulses pf electricity through a coil of wire placed next to the skull
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ROD photoreceptors
responsible for bringing light to the image or stimulus; peripherial vision ("on the side")
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Cone Photoreceptors
responsible for bringing color to the image or stimulus
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Sensory Transduction
the process by which sensory stimuli are transduced into slow, graded receptor potentials
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Fovea
region of the retina that mediates the most acute vision of birds and higher mammals; color-sensitive cones constitute the only type of photoreceptor found here
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Optic disk
exit point from the retina ganglion cell axons (fibers) that form the optic nerve; responsible for the blind spot
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Accomidation
changes in the thickness of the lens of the eye, acomplished by the ciliary muscles, that focus images of near or distant objects on the retina
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Bipolar cells
a bipolar neuron located in the kiddle layer of the retina, conveying information from the photoreceptors to the ganglion cells
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ganglion cells
a neuron located in the retina that recieves visual information from bipolar cells; its axons give rise to the optic nerve
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LGN
a group of cell bodies wuthin the lateral geniculate body of the thalemus; recieves inputs from the retina and projects to the primary visual cortex
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LGN: Magnocellular layer
transmits information necessary for the perception of form, movement, depth, and small diffrences in brighness to the primary visual cortex
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LGN: parvocellular layer
transmits info necessary for perception of color and fine details to the primary visual cortex
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Optic Chaism
the "cross roads" where the message crosses the visual field
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Receptive field
tha portion of the visual field in which the presentation of visual stimuli will produce an alteration in te fireing rate of a particular neuron
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Thomas Young
proposed that the eye detetected diffrent colors because it contained 3 types of receptors, each sensitive to a single hue (Trichromatic theory); helps to explain inherited forms of color blindness
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Protanopia (trichromatic theory)
red and green cones are confused; "red" cones are filled by "green" cone opsin
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Deuteranopia (trichromatic theory)
red and green cones are confused; "green" cones are filled with "red" cone opsin
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Trianopia (trichromatic theory)
hues with short wavelenghts are confused; "blue" cones are either lacking or faulty
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Striatic Cortex (simple cells)
orientation-sensitive neuron whos receptive field is organized in an opponent fashion
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Striatic Cortex (complex cells)
a neuron in the visual cortex that responds to the presense of a line segment with a particular orientation located within its receptive field, especially when the line moves perpendicularly to its orientation
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Striatic Cortex (hypercomplex Cells)
neuron in the visual cortex that responds to the presense of a line segment with a particular orientation that ends at a particular point within the cells receptive field
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Extrastriatic cortex
region in the visual association cortex; recieves fibers from the striate cortexand from the superior colliculi and projects to the inferior temporal cortex; each region contains one or more independant maps of the visual field
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Dorsal stream (“where”/”how” pathway)
interconnected regions of visual cortex involved in the perception of SPATIAL LOCATION; striate cortex-->posterior parietal cortex/lobe
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Ventral stream (“what” pathway)
interconnected regions of visual cortex involved in the perception of FORM; striate cortex-->inferior temporal cortex/lobe; Lateral occipital complex (LOC) involved in object perception; Extrastriate body area (EBA) involved in body parts other than face; PPA area is involved in scenes,areas
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