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Electrolytes
Chemical substances that develop anelectric charge and are able to conduct an electric current when placed in water; ions
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Cation
Ions that carry a positive charge
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Anion
Ions that carry a negative charge
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What do electrolytes do?
- Regulate fluid blance and hormone production
- Strengthen skeletal structures
- Act as catalysts in nerve response, muscle contraction, and the metabolism of nutrients
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Hypovolemia-isotonic
- Fluid Volume Deficit
- Loss of water and electrolytes from the ECF
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Dehydration-Osmolar
- Fluid Volume Deficit
- Loss of water with no loss of electrolytes
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Dehydration results in an increase in what three things?
- Hematocrit
- Serum electrolytes
- Urine specific gravity
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Hypervolemia-isotonic
- Fluid Volume Excess
- Water and Sodium retained in abnormally high proportions
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Overhydration-osmolar
- Fluid Volume Excess
- More water gained than electrolytes
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Sever hypervolemia can lead to ____ and ____.
- Pulmonary edema
- Heart Failure
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Overhydration results in decreases of what three things?
- Hematocrit
- Serum electrolytes
- Protein
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Major electrolytes in the body
- Sodium
- Potassium
- Chloride
- Magnesium
- Phosphorous
- Calcium
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Sodium
- Major electrolyte found in the ECF
- Essential for maintenance of acid-base balance, active and passive transport mechanisms, and irritability and conduction of nerve and muscle tissue
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Normal serum sodium levels
Between 136 and 145 mEq/L
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Hyponatremia
- Serum sodium levels less than 136 mEq/L
- Net gain of water or loss of sodium-rich fluids
- Water moves from ECF to ICF causing cells to swell
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Hypernatremia
- Serum Sodium level more than 145 mEq/L
- Serious electrolyte imbalance;can cause significant neurological, endocrine, and cardiac disturbances
- Cells become dehydrated
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Potassium
- Major cation in ICF
- Plays a vital role in cell metabolism; transmission of nerve impulses; functioning of cardiac, lung, and muscle tissues; and acid-base balance
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Normal serum potassium levels
3.5 to 5 mEq/L
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Hypokalemia
- Serum potassium level less than 3.5 mEq/L
- Result of an increased loss of potassium from the body or movement of potassium into the cells
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Hyperkalemia
- Serum potassium levels more than 5 mEq/L
- Result of an increased intake of potassium, movement of potassium out of the cells, or inadequate renal excretion
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Calcium
Essential for proper functioning of the CV, neuromuscular, and endocrine systems, as well as blood clotting and teeth formation
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Normal calcium levels
9 to 10.5 mg/dL
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Hypocalcemia
Serum calcium level less than 9 mg/dL
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Normal Magnesium levels
1.5 to 2.5 mEq/L
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Hypomagnesemia
Seum magnesium level less than 1.5 mEq/L
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Function of Sodium
Major contributor to maintaining water balance
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Regulatory Mechanism of Sodium
Dietary intake and aldosterone secretion
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Function of Potassium
Is necessary for glycogen deposits in the liver and skeletal muscle, transmission and conduction of nerve impulses, normal cardiac conduction, and skeletal and smooth muscle contraction
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Regulatory Mechanism of Potassium
Dietary intake and renal excretion regulate potassium.
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Function of Calcium
Bone and teeth formation, blood clotting, hormone secretion, cell membrane integrity, cardiac conduction, transmission of nerve impulses, and muscle contraction
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Regulatory Mechanism of Calcium
Absorbed from intestine, excreted by the kidneys and resorption or deposition in bone. Regulated by parathyroid hormone, vitamin D & calcitonin.
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Function of Magnesium
Essential for enzyme activities, neurochemical activities, and cardiac and skeletal muscle excitability
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Regulatory Mechanism of Magnesium
Serum magnesium is regulated by dietary intak, renal mechanisms, and actions of the parathyroid hormone (PTH).
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Normal Chloride Levels
95-105 mEq/L
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Function of Chloride
Chloride is the major anion in ECF. The transport of chloride follows sodium.
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Regulatory Mechanism of Chloride
Serum chloride is regulated by dietary intake and the kidneys
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Normal Levels of Bicarbonate
- 22-26 (arterial) mEq/L
- 24-30 (venous) mEq/L
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Function of Bicarbonate
The bicarbonate ion is an essential component of the carbonic acid-bicarbonate buffering system essential to acid-base balance.
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Regulatory Mechanism of Bicarbonate
The kidneys regulate bicarbonate.
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Normal Phosphate Levels
2.8-4.5 mg/dL
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Function of Phosphate
It assists in acid-base regulation. Phosphate and calcium help to develop and maintain bones and teeth. Phosphate also promotes normal neuromuscular action and participates in carbohydrate metabolism.
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Regulatory Mechanism of Phosphate
Phosphate is normally absorbed through the GI tract. It is regulated by dietary intake, renal excretion, intestinal absorption, and PTH.
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Lab Values of Hyponatremia
- serum sodium level below 135 mEq/L
- serum osmolality 280 mOsm/kg
- urine specific gravity below 1.010 (if not caused by SIADH)
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Signs and Syptoms of Hyponatremia
- apprehension
- personality change
- postural hypotension
- postural dizziness
- abdominal cramping
- nausea and vomiting
- diarrhea
- tachycardia
- dry mucous membranes
- convulsions
- coma
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Lab values of Hypernatremia
- serum sodium levels above 145 mEq/L
- serum osmolality 300 mOsm/kg
- urine specific gravity 1.030 (if not caused by diabetes insipidus)
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Signs and Syptoms of Hypernatremia
- extreme thirst
- dry and flushed skin
- dry and sticky tongue and mucous membranes
- postural hypotension
- fever
- agitation
- convulsions
- restlessness
- irritability
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Lab Values of Hypokalemia
- serum potassium level below 3.5 mEq/L
- electrocardiogram (ECG) abnormalities: flattened T wave; ST segment depression; u wave; potentiated digoxin effects (e.g., ventricular dysrhythmias)
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Signs and Symptoms of Hypokalemia
- weakness and fatigue
- muscle weakness
- nausea and vomiting
- intestinal distention
- decreased bowel sounds
- decreased deep tendon reflexes
- ventricular dysrhythmias
- paresthesias
- weak, irregular pulse
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Lab Values of Hyperkalemia
- serum potassium level above 5.0 mEq/L
- ECG abnormalities: peaked T wave and widened QRS complex (bradycardia, heart block, dysrhythmias); eventually QRS pattern widens, and cardiac arrest occurs
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Signs and Symptoms of Hyperkalemia
- anxiety
- dysrhythmias
- paresthesia
- weakness
- abdominal cramps
- diarrhea
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Lab Values of Hypocalcemia
- serum ionized calcium level below 4.5 mEq/L OR total serum calcium below 8.5 mg/dL
- ECG abnormalities: ventricular tachycardia
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Signs and Symptoms of Hypocalcemia
- numbness and tingling of fingers and circumoral (around mouth) region
- hyperactive reflexes
- positive Trousseau’s sign (carpopedal spasm with hypoxia)
- positive Chvostek’s sign (contraction of facial muscles when facial nerve is tapped)
- tetany
- muscle
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Lab Values of Hypercalcemia
- serum ionized calcium level above 5.5 mEq/L or total serum calcium level above 10.5 mg/dl
- x-ray examination showing generalized osteoporosis, widespread bone cavitation, radiopaque urinary stone
- elevated blood urea nitrogen (BUN) level 25 mg/100 ml
- elevated creatinine level 1.5 mg/100 ml caused by fluid volume deficit (FVD) or renal damage caused by urolithiasis
- ECG abnormalities: heart block
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Signs and Symptoms of Hypercalcemia
- anorexia
- nausea and vomiting
- weakness
- hypoactive reflexes
- lethargy
- flank pain (from kidney stones)
- decreased level of consciousness
- personality changes
- cardiac arrest
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Lab Values of Hypomagnesia
serum magnesium level below 1.5 mEq/L
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Signs and Symptoms of Hypomagnesia
- muscular tremors
- hyperactive deep tendon reflexes
- confusion and disorientation
- tachycardia
- hypertension
- dysrhythmias
- positive Chvostek’s sign and Trousseau’s sign
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Lab Values of Hypermagnesia
- serum magnesium level above 2.5 mEq/L
- ECG abnormalities: prolonged QT interval, AV block
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Signs and Symptoms of Hypermagnesia
- acute elevations in magnesium levels
- hypoactive deep tendon reflexes
- decreased depth and rate of respirations
- hypotension
- flushing
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