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What vasodilator is effective ifor HTN in low renin, elderly, and Afircan Americans?
Nifedipine
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What does ACE I do to K concentrations?
- Increase
- Distal tubule, decrease Na uptake, decrease K excretion, decrease H excretion --> metabolic acidosis
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When is it indicated to take Nitrates?
TIme of angina attack and in anticipation of acute exercize/stress
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What are the uses for soduim Nitroprusside?
Emergency HTN, severe heart failure
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What's different about the activation of sodium nitroprusside vs. Nitroglycerin?
- Sodium Nitroprussdie - spontaneous non-enzymatic release of NO
- Nitro - Avoid first pass metabolism in liver via spray/sublingual
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Tx for V-tach with remote MI
Amoiderone or Lidocaine
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What's first line DVT treatment?
LMWH
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What's the interaction between Cimetidine and Warfirin?
- Increased warfarin effect due to decreased metabolism of warfarin (CYP450);
- also alcohol, asprin, cimetidine, amioderone
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Direct Thrombin Inhibitors (renal/liver metabolism)
- Liver: argatroban
- Kidney: lepirudin, bivalirudin
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Which anti hyperlipidemia drugs are safe for pregnant women?
Bile Resins (prevent absorption of bile)
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What's the treatment for Osteoperosis?
Bisphoshonates (aldronate, -nates)
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Why are corticosteroids good treatment for asthma?
High rate of first pass metabolism (after acting on primary target..bronchioles, deactivated in liver)
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What are side effects Oral Contraceptives?
Breast Tenderness, depression, fluid retention, weight gain, decreased risk for cancer
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