Study Guide Chapters 10, 11 Pharmacology

  1. Another name for surface-active agents is:

    C. detergent
  2. For an alveolus, LaPlace's Law is written as:

    A. pressure = (2 x surface tension)/radius
  3. Lack of pulmonary surfactant in respiratory distress syndrome of the newborn results in:

    D. high surface tension
  4. The term used to describe surfactant produced outside of the patient's body is:

    D. exogenous
  5. Surfactant is produced by:

    C. alveolar type II cells
  6. Surfactant is composed primarily of :

    D. phospholipids
  7. Surfactant is stored in:

    B. lamellar bodies
  8. The major stimulus for secretion of surfactant into the alveolus is:

    B. lung inflation
  9. Which of the following are natural surfactant preparations?
    I. surfaxin
    II. curosurf
    III. survanta
    IV. infasurf

    A. II, III, and IV
  10. Natural surfactant is obtained by all of the following methods except:

    D. in vitro preparation
  11. Which of the following are approved indications for surfactant therapy?
    I. prophylaxis in very low birth wight (<1250 g infants)
    II. prophylaxis in infants of higher birth weight (>1250 g) but with immature lungs
    III. rescue treatment in infants with respiratory distress syndrome
    IV. acute respiratory distress syndrome in the adult

    D. I, II, and III only
  12. Which of the following are currently used methods for delivering surfactant into infants?
    I. instillation through side-port catheter
    II. instillation through catheter
    III. nebulization
    IV. ECMO

    D. I and II only
  13. You are in the room of a 36-week gestationa baby that has just been born. The newborn weighs 2200 g. On assessment you find the baby has good color, no retractions, no nasal flaring, a RR of 25, a HR of 110, and a pulse-ox of 96% on room air. Which of the following would you choose?

    B. no indication for therapy at this time
  14. A newborn baby weighing 1000 g exhibits symptoms of RDS, including poor color, suprasternal retractions, nasal flaring, and desaturations. The therapist should recommend:

    C. poractant alfa
  15. All the following are considered natural surfactants except:

    C. dornase alfa
  16. The usual method of administering exogenous surfactant to babies is:

    B. direct instillation to the airway
  17. Which of the following is considered the mode of action for surfactant?

    B. to replace missing surfactant
  18. All the following are hazards or complications of exogenous surfactants except:

    A. tachycardia
  19. You are in the room of a 26-week gestational baby that has just been born. The newborn wieghs 1200 g. On assessment you find the baby has poor color, substernal retractions, nasal flaring, RR of 45, HR of 140. You note that the baby is difficult to bag. Which of the following agents wyould you recommend?

    B. beractant
  20. A significant side effect of corticosteroid use is inhibition of:

    B. HPA axis
  21. All of the following are types of corticosteroids produced in the adrenal cortex except:

    A. corticotropin-releasing factor
  22. Corticosteroids normally produced by the body are known as:

    D. endogenous
  23. Which of the following are examples of steroids available for inhalation?
    I. flunisolide
    II. azmacort
    IV. interleukin

    B. I, II, and III only
  24. The rise and fall of levels of glucocorticoids in the body follows what kind of rhythm?

    B. circadian
  25. The inflammatory process includes which of the following activities?
    I. mediator cascade
    II. incr vasular permeability
    III. leukocytic infiltration
    IV. phagocytosis

    D. I, II, III, and IV
  26. The major cells responsible for an inflammatory response in asthma are:

    B. mast cells and eosinophils
  27. The early phase of an astmatic reaction occurs during what time frame?

    A. 15 min to an hour
  28. The product combining an inhaled steroid and a bronchodilator is:

    B. advair
  29. Side effects of systemic steroid treatment include which of the following?
    I. HPA suppression
    II. cough
    III. dysphonia
    IV. psychiatric reactions

    C. I and IV only
  30. Side effects of aerosolized steroid use include all of the following except:

    D. osteoporosis
  31. In COPD, the primary inflammatory cells are:

    C. neutrophils
  32. The steroids responsible for secondary male sex characteristics are known as:

    B. androgenic
  33. Corticosteroids are used with asthmastics and COPD patients to achieve which effect?

    B. antiinflammatory
  34. Use of oral steroids for long periods of time can cause:

    D. HPA suppression
  35. In what dosage form is/are corticosteroids available for use in the US?

    D. all of the above
  36. Which of the following is a common side effect of inhaled corticosteroids?

    C. oral candidiasis
  37. A patient has been taking oral prednisone for 1 week following a severe episode of asthma. The physician decides to switch the patient to aerosolized beclomethasone (QVAR). What is the best way to accomplish this?

    C. begin the aerosol and begin to gradually taper off the oral dose
  38. A patient complains of oral thrush and hoarseness since she has been using fluticasone by MDI. The physician asks you to make a suggestion to help her without discontinuing the drug. You suggest:

    A. add a spacer and rinse the mouth after use
  39. Use of systemic corticosteroids can cause all of the following, except:

    A. incr endogenous steroid production
  40. Your patient tells you that she is having chest tightness and wheezing four to six times per week, plus she wakes up with chest tightness and wheezing about once per week. She uses albuterol each time, with relief. She is taking no other medication, except her albuterol MDI. What other medication would you suggest be prescribed for her?

    A. beclomethasone MDI
Card Set
Study Guide Chapters 10, 11 Pharmacology
Part 3 of 3 for test on chapters 6-11