Study Guide Chapters 8,9 Pharmacology

  1. The mechanism of action by xanthines is:

    D. unclear
  2. Theophylline has been used to treat all of the following except:

    B. pneumonia
  3. The xanthine of choice to treat apnea of prematurity is:

    C. caffeine citrate
  4. Theophylline and caffeine are examples of:

    D. methylxanthines
  5. Theophylline is classified as a bronchodilator because it:

    D. has a relaxing effect on bronchial smooth muscle
  6. Xanthines have all the following physiological effects except:

    A. cerebral vasodilation
  7. Which drug stimulates skeletal muscle and the CNS most strongly?

    B. caffeine
  8. An incr in intracellular cyclic adenosine 3',5'-monophosphate (cAMP) causes:

    C. bronchial smooth muscle relaxation
  9. It is difficult to determine therapeutic doses of theophylline because:

    C. individuals metabolize theophylline at different rates
  10. The currently recommended blood serum theophylline level for the management of asthma is:

    D. 5 to 15 micrograms/ml
  11. The recommended therapeutic blood serum range of theophylline for use in the treatment of COPD is:

    B. 10 to 12
  12. Dosage of theophylline is best monitored by:

    C. measurement of serum drug levels
  13. Theophylline blood levels can be increased by all of the following except:

    b. B blockers
    A. B agonists
  14. Common, less toxic side effects of theopylline therapy include which of the following?
    I. h/a
    II. gastric upset
    III. anxiety
    IV. nervousness
    V. diuresis

    C. I, II, III, IV, and V
  15. A decr in blood theophylline levels could be caused by all of the following except:

    A. renal failure
  16. Disadvantages of theophylline therapy include which of the following:
    I. narrow therapeutic margin
    II. toxic effects
    III. unpredictable blood levels
    IV. need for individual dosing
    V. numerous drug-drug and drug-condition interactions
    all (five) of the above
  17. Nonbronchodilating effects of theophylline include all the following except:

    B. incr pulmonary vascular resistance
  18. You are working the night shift when a 68-year-old COPD patient is admitted through the ER. He has been given combivent and inhaled corticosteroids. The intern on call asks your recommendation for additional medication to give the patient. You would recommend:

    D. theophylline
  19. A significant side effect of theophylline often seen in patients is:

    A. nausea
  20. The therapeutic range for theophylline is:

    C. 10 to 20
  21. There are many possible explanations of how theophylline works. All of the following are possible theories except:

    c. produces catecholamines
    C. blocks acetylcholine
  22. Which of the following is not a function of mucus in the body?

    C. improvement of gas exchange
  23. Diseases with hypersecretion or poor clearance of secretions include which of the following?
    I. cystic fibrosis
    II. pneumonia
    III. CHF
    IV. primary ciliary dyskinesia

    D. I, II, and IV only
  24. Medications that incr mucociliary or cough efficiency are:

    C. mucokinetics
  25. The number of goblet cells per square mm of normal airway mucosa is:

    B. 6000
  26. What structure is responsible for providing the majority of mucus secretions?

    B. submucosal glands
  27. In peripheral airways the rate of mucociliary transport in the normal peripheral aiway is approx:

    B. 1.5 mm/min
  28. The cholinergic (sympathetic) response in terms of mucociliary clearance is:
    I. incr ciliary beat
    II. decr ciliary beat
    III. incr mucus production
    IV. decr mucus production

    D. I and III only
  29. Antibaccterial defense in the airway is provided by which of the following?
    I. IgA
    II. IgG
    III. Phospholipids
    IV. Serine proteases

    A. I, II, and IV only
  30. What mucus color indicates retainedf secretions and neutrophil activation?

    D. green
  31. The physical properties of mucus include which of the following?
    I. adhesion
    II. cohesion
    III. elasticity
    IV. viscosity

    D. I, II, III, and IV
  32. Which of the following agents is/are currently approved for administration as an aerosolized mucoactive agent?
    I. dry powder mannitol
    II. N-acetylcysteine (NAC)
    III. dornase alfa
    IV. ipratropium bromide

    A. II and III only
  33. All of the following are hazards associated with the use of acetylcysteine except:

    B. tachycardia
  34. Pulmozyme is the trade name for the mucoactive agent:

    D. dornase alfa
  35. The standard dose of dornase alfa for aerosolization is:

    B. 2.5 mg in 2.5 m. of diluent
  36. Agents that incr volume or hydration of airway secretions are called:

    D. expectorants
  37. The expectoranct that may stimulate the cholinergic pathway to incr mucus secretion is:

    C. guaifenesin
  38. You have a patient with COPD who is struggling to expel viscid mucus plugs. What would you recommend for this problem?

    D. acetylcysteine
  39. A resident orders 4 cc of 20% mucomyst aerosolized for an asthma patient. You are called by the unit secretary about te order. You would:

    B. call the resident and obtain a verbal order to give a B2 agonist with the mucomyst
  40. All the following nebulizers have been tested and approved for use with dornase alfa except:

    C. Misty-Neb
  41. Acetylcysteine is incompatible in solution with which of the following:

    C. certain antibiotics
  42. How does dornase alfa work?

    C. breaks down DNA content in sputum
  43. How does acetylcysteine (mucomyst) work?

    A. substitutes sulhydryl radicals for disulfide bonds to mucus
Card Set
Study Guide Chapters 8,9 Pharmacology
Part 2 of 3 for Test for Chapters 6-11