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Calcium
Rise in Ca both nec and suff for NT release
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SV proteins
- SYNAPTOMTAGMIN (Ca sensor)
- synapsin
- synaptobrevin (SNARE)
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Presynaptic membrane prot
- Ca channels (ca influx)
- SNAP-25 (SNARE)
- syntaxin (SNARE)
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SV priming and fusion
- components of the SNAREs
- syntaxin, synaptobrevin, SNAP-25
*Botulism- cleane SNARE< impairment of NT release
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SV fussion
Ca-synaptotagmin-triggeres fussion
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IonotrophicR
- ligand-gated R, fast (ms)
- cation selective-excit. inputs
- chloride selective- inhibitory inputs (GABAA & glycineR)
pentamer (5 subunit); each 4 trans
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MetabotrophicR
- slow (ms-min)
- single 7 transmemb domain pept
single polypept; each 7 trans
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dense cores
- Ach and aa: small clear v: 40-60nm diam
- Biogenic amines: small dense-core v: 40-60 or larger
- Neuropetides: large dense-core v: 90-250nm
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Reuse
small-molecule NTs: specific uptake transporters, recyles **except Ach- gegraded in cleft
NPT- proteolytically degraded outside cell
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nAChR
*myesthenia gravis- autoimmune that affect nAChR.. weakness.
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NMDAR
- "coincidence R"
- need bindin of glutamate & depol
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long-range attraction/repulsion
netrin (can be long-range retractant as well dep on Rs!)
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short range repulsion
ephrins in eye
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short range attraction
- fasciculation
- 1. follow second
- 2. pioneer ns
- 3, regeneration (in PNS. CNS has lots of short range repulsive signals)
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