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Calcium
Rise in Ca both nec and suff for NT release
SV proteins
SYNAPTOMTAGMIN (Ca sensor)
synapsin
synaptobrevin (SNARE)
Presynaptic membrane prot
Ca channels (ca influx)
SNAP-25 (SNARE)
syntaxin (SNARE)
SV priming and fusion
components of the SNAREs
syntaxin, synaptobrevin, SNAP-25
*Botulism- cleane SNARE< impairment of NT release
SV fussion
Ca-synaptotagmin-triggeres fussion
IonotrophicR
ligand-gated R, fast (ms)
cation selective-excit. inputs
chloride selective- inhibitory inputs (GABA
A
& glycineR)
pentamer (5 subunit); each 4 trans
MetabotrophicR
slow (ms-min)
single 7 transmemb domain pept
single polypept; each 7 trans
Excit
Erev>thresh
Inhib
Erev<thresh
dense cores
Ach and aa
: small clear v: 40-60nm diam
Biogenic amines
: small dense-core v: 40-60 or larger
Neuropetides
: large dense-core v: 90-250nm
Reuse
small-molecule NTs: specific uptake transporters, recyles **except Ach- gegraded in cleft
NPT- proteolytically degraded outside cell
nAChR
*myesthenia gravis- autoimmune that affect nAChR.. weakness.
NMDAR
"coincidence R"
need bindin of glutamate & depol
long-range attraction/repulsion
netrin (can be long-range retractant as well dep on Rs!)
short range repulsion
ephrins in eye
short range attraction
fasciculation
1. follow second
2. pioneer ns
3, regeneration (in PNS. CNS has lots of short range repulsive signals)
Author
pretty4Jesus
ID
76614
Card Set
Synapse
Description
synapses
Updated
2011-04-01T17:49:26Z
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