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What classes?
- Thiazide diuretics
- Beta blockers
- Vasodilators (Ca channel blocker & alpha 1 receptor blockers)
- Drugs affecting renin-angiotensin system (ACE & Angiotensin II inhibitors)
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Chlorothiazide
- Thiazide diuretc
- Inhibit Na & Cl absorbtion in distal convoluted tubule
- Mild-moderate HyT
- Increase loss of K
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Propanolol
- Beta-blocker
- Prevent beta receptors to naturally in crease Ht rate & force of contraction
- Mild-moderate HyT (no asthma!)
- Ht failure, brochospasm
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Atenolol
- Beta-blocker
- Prevent beta receptors to naturally increase Ht rate & force of contraction
- Mild-moderate HyT (no asthma!)
- Ht failure, brochospasm
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Nifedipine
- Vasodilator - calcium channel blocker
- Act on Ca channels to block contractions of cardiac + smooth muscle and dilate vessels
- HyT (used in comb with beta-blockers)
- Dizziness, nausea, drop in BP
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Verapamil
- Vasodilator - calcium channel blocker
- Act on Ca channels to block contractions of cardia + smooth muscle and dilate vessels
- HyT (not used in comb with beta-blockers)
- Nausea, fever, sore throat, heachache
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Prazosin
- Vasodilator - alpha 1 receptor blocker
- Inhibit alpha receptor on smooth muscle through blocking constrictor effect of noradrenline/adrenalie (catecholamines
- HyT (in comb with diuretics)
- Postural hypotension
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Captopril (original)
- ACE inhibitor (act on ACE to modify activity of angiotensin II)
- Blocks ACE to vasoconstrict, remodel vessels, release aldosterone, retain Na
- Mild-moderate HyT, Ht failure
- Dry cough, headache, fatigue
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Lisinopril
- ACE inhibitor (act on ACE to modify activity of angiotensin II)
- Blocks ACE to vasoconstrict, remodel vessels, release aldosterone, retain Na
- Mild-moderate HyT, Ht failure
- Dry cough, headache, fatigue
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Irbesartan
- Angiotensin II receptor inhibitor (act on angiotensin II to block binding with AT1 receptors)
- HyT
- Hypotension, tachycardia
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