-
Bacteriology vs. Mycology
- Study of fungi is more simple than bacteria
- – Colony morphology
- – Microscopic structures
- – Smaller field
- • Only about 60 consistent species
- – Biochemical tests seldom used
- • Person to person transmission very rare
- – Outbreaks can usually be traced to common source
-
Fungi
Def: “a group of non-motile eukaryotic organisms that have definite cell walls, are devoid of chlorophyll, and reproduce by means of spores (and conidia)”
- Heterotrophic, Eukaryotic Vs. prokaryotic
-
-
• Capsule
- • Cell wall
- • Cell membrane
- • Cytoplasm
- – Nucleus, nucleolus, nuclear membrane, ER, mitochondria, vacuoles
-
-
• Polysaccharide
- – Much larger than bacterial capsule
- • Antiphagocytic, virulence
- -Prevents the organism from being targeted during phagocytosis.
- - allows the organism to control its local environment
- • Mostly in yeast
- – Cryptococcus neoformans – encapsulated yeast
-
-
• Antigenic portion of the yeast
- • Multilayered
- – Polysaccharides (90%)
- – Chitin
- – Proteins and glycoproteins (10%)
- • Provides shape and rigidity to cell
- – Osmotic protection
- -offers the best unique structures compares to mammalian cells as a target for antifungal agents
-
-
• Bilayered phospholipids
- • Sterols (ergosterol- fungal vs. cholesterol- mammalian)
- - Ergosterol provides a target for antifungal agents
- • Functions:
- – Protects cytoplasm
- – Regulates intake of nutrients
- – Facilitates capsule and cell wall synthesis
-
Hyphae
filamentous, tubular growth
-
True hyphae
tubular structure where cross was or symplate will form as a structure
-
-
yeast cells reproducing end on end
-
-
-
-
-
-
-
matt of hyphae that occurs while the organism grows
– Vegetative- point downward into the gound– Aerial- reaises up in to the air
-
-
Yeasts
unicellular, budding
-
Dimorphic
- two bodies or forms where they will have both a mold and yeast form.
- Most important are those that are thermally dimorphic
-
Perfect fungi
sexual stage is known and is well described
-
-
no known sexual stage or not discribed
-
Conidia
Reproductive structures produced by an asexual mode
-
-
Reproductive structures produced sexually, and the asexual reproductive cells of the Zygomycetes
-
Asexual reproduction
Conidiophore & Sporangium
-
-
– structure that supports conidia
- – Anelloconidia – produced by anellides
- – Phialoconidia – produced by phialide
- – Poroconidia – produced from pores
-
Sporangium
saclike structure where sporangiospores are formed (Zygomycetes)
|
|