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Class
Short acting benzodiazepine CNS depressant
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Mechanism of action
Anxiolytic and sedative properties similar to other benzodiazepines, memory impairment.
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Indications
Sedation, anxiolytic prior to endotracheal or nasotracheal intubation; administer for conscious sedation.
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Contraindications
Glaucoma, shock, coma, alcohol intoxication, oversdose, depressed vital signs, concomitant use with other CNS depressants, barbiturates, alcohol, narcotics.
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Adverse reactions
Hiccough, cough, oversedation, nausea, vomiting, injection site pain, headache, blurred vision, hypotension, repiratory depression, and arrest.
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Drug interactions
Should not be used in Pts. who have taken a CNS depressant.
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How supplied
2, 5, 10 mL vials (1mg/mL); 1, 2, 5, 10 mL vials (5mg/mL).
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Dosage and Administration
- Adult: 2.0-2.5 mg slow IV over 2-3 minutes; may be repeated to total maximum: 0.1 mg/kg.
- Pediatric: Not recommended
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Duration of action
- Onset: 1-3 minutes, IV and dose dependent
- Peak effect: variable
- Duration: 2-6 hours, dose dependent
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Special Considerations
- Pregnancy safety: Category D.
- Administer immedialty prior to intubation procedure. Requires continuous monitoring of respiratory and cardiac function. Never administer as IV bolus.
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