1. Trade Name
  2. Class
    Short acting benzodiazepine CNS depressant
  3. Mechanism of action
    Anxiolytic and sedative properties similar to other benzodiazepines, memory impairment.
  4. Indications
    Sedation, anxiolytic prior to endotracheal or nasotracheal intubation; administer for conscious sedation.
  5. Contraindications
    Glaucoma, shock, coma, alcohol intoxication, oversdose, depressed vital signs, concomitant use with other CNS depressants, barbiturates, alcohol, narcotics.
  6. Adverse reactions
    Hiccough, cough, oversedation, nausea, vomiting, injection site pain, headache, blurred vision, hypotension, repiratory depression, and arrest.
  7. Drug interactions
    Should not be used in Pts. who have taken a CNS depressant.
  8. How supplied
    2, 5, 10 mL vials (1mg/mL); 1, 2, 5, 10 mL vials (5mg/mL).
  9. Dosage and Administration
    • Adult: 2.0-2.5 mg slow IV over 2-3 minutes; may be repeated to total maximum: 0.1 mg/kg.
    • Pediatric: Not recommended
  10. Duration of action
    • Onset: 1-3 minutes, IV and dose dependent
    • Peak effect: variable
    • Duration: 2-6 hours, dose dependent
  11. Special Considerations
    • Pregnancy safety: Category D.
    • Administer immedialty prior to intubation procedure. Requires continuous monitoring of respiratory and cardiac function. Never administer as IV bolus.
Card Set
Paramedic Pharmacology