1. Trade Name
  2. Class
    Anti-inflammatory glucocorticoid
  3. Mechanism of action
    Synthetic corticosteroid that suppresses acute and chronic inflammation; potentiates vascular smooth muscle relaxation by beta-adrenergic agonists.
  4. Indications
    Acute spinal cord trauma, anaphylaxis, bronchodilator for unreponsive asthma.
  5. Contraindications
    Premature infants, systemic fungal infections, use with caution in pts. with gastrointestinal bleeding.
  6. Adverse reactions
    Headache, hypertension, sodium and water retention, CHF, Hypokalemia, alkalosis, peptic ulcer disease, nausea, vomiting.
  7. Drug interactions
    Hypoglycemic responses to insulin and hypoglycemic agents may be blunted. Potassium-depleting agents may exacerbate hypokalemia effects.
  8. How supplied
    40, 125, 500, and 1,000 mg vials
  9. Dosage and Administration
    • Adult: acute spinal cord injury-30 mg/kg IV over 30 minutes followed by infusion: 5.4 mg/kg/h. Asthma, COPD: 1-2 mg/kg IV.
    • Pediatric: acute spinal cord trauma: 30 mg/kg IV over 30 minutes; infusion: 5.4 mg/kg/h. Asthma: 1-2 mg/kg/dose IV.
  10. Duration of action
    • Onset of action: 1-2 hours.
    • Peak effects: variable
    • Duration of action: 8-24 hours
  11. Special considerations
    Pregnancy safety: not established. Not effective if spinal cord injury greater than 8 hours. Crosses the placenta and may cause fetal harm.
Card Set
Paramedic Pharmacology