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Adenocarcinoma
Cancer in glandular tissue
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Anaphase
The fourth stage of mitosis, beginning when sister chromatids separate from each other and ending when a complete set of daughter chromosomes have arrived at each of the two poles of the cell
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Anchorage dependence
The requirement to divide, a cell must be attached to a solid surface
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Angiogenesis
A physiological process involving the growth of new blood vessels from pre-existing vessels
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Asexual reproduction
The creation of offspring by a single parent, without the participation of sperm and egg
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Autosomes
A chromosome not directly involved in determining the sex of an organism; in mammals, for example, any chromosome other than X or Y
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Benign tumor
An Abnormal mass of cells that remains at its original site in the body
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Binary fission
A means of asexual reproduction in which a parent organism, often a single cell, divides into two individuals of about equal size
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Cancer cell
A cell that is not subject to normal cell cycle control mechanisms and that will therefore divide continuously
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Carcinomas
Cancer that originates in the coverings of the body, such as skin or lining of the intestinal tract
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Cell cycle
An ordered sequence of events (including interphase and the mitotic phase that extends from the time a eukaryotic cell is first formed from a dividing parent cell until its own disjoin into two cells
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Cell cycle control system
a cyclically operating set of proteins that triggers and coordinates events in the eukaryotic cell cycle
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Cell division
The reproduction of a cell
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Cell plate
A double membrane across the midline of a dividing plant cell, between which the new cell wall, between which the new cell wall forms during cytokinesis
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Centromere
The region of a chromosome where two sister chromatids are joined and where spindle microtubules attach during mitosis and meiosis. The centromere divides at the onset of anaphase during mitosis and anaphase II during meiosis
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Centrosomes
Material in the cytoplasm of a eukaryotic cell that gives rise to microtubules; important in mitosis and meiosis; also called microtubule-organizing center
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Chromatin
The combination of DNA and proteins that constitutes chromosomes; often used to refer to the diffuse, very extended form taken by the chromosomes when a eukaryotic cell is not dividing
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Chromosomes
A threadlike, gene-carrying structure found in the nucleus of a eukaryotic cell and most visible during mitosis and meiosis; also, the main gene-carrying structure of a prokaryotic cell. Chromosomes consist of chromatin.
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Cleavage furrow
The first sign of cytokinesis during cell division in an animal cell; a shallow groove in the cell surface near the old metaphase plate
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Cytokinesis
The division of the cytoplasm to form two separate daughter cells. Cytokinesis usually occurs during telophase of mitosis, and mitosis and cytokinesis make up the mitotic (M) phase of the cell cycle
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Density dependent inhibition
The arrest of cell division that occurs when cells grown in a laboratory dish touch one another; generally due to an inadequate supply of growth factors
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Diploid
A cell or an organism consisting of two sets of chromosomes: usually, one set from the mother and another set from the father. In a diploid state the haploid number is doubled, thus, this condition is also known as 2n
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Dysplasia
Abnormality in maturation of cells within a tissue
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Fertilization
The union of the nucleus of a sperm cell with the nucleus of an egg cell, producing a zygote
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Gamete
A sex cell; a haploid egg or sperm. The union of two gametes of opposite sex (fertilization) produces a zygote
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Genome
A complete (haploid) set of an organism's genes; an organism's genetic material
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Haploid cell
In the life cycle of an organism that reproduces sexually, a cell containing a single set of chromosomes; an n cell
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Interphase
The period in the eukaryotic cell cycle when the cell is not actually dividing
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Kinetochore
A specialized protein structure at the centromere region on a sister chromatid. Spindle microtubules attach to the kinetochore during mitosis and meiosis
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Leukemia
A cancer of the blood or bone marrow characterized by an abnormal proliferation of blood cells, usually leukocytes
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Lymphomas
Cancer of the tissues that form white blood cells
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Malignant tumor
An abnormal tissue mass that can spread into neighboring tissue and to other parts of the body; a cancerous tumor
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Meiosis
In a sexually reproducing organism, the division of a single diploid nucleus into four haploid daughter nuclei. Meiosis and cytokinesis produce haploid gametes from diploid cells in the reproductive organs of the parents
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Metaphase
The third stage of mitosis, during which all the cell's duplicated chromosomes are lined up at an imaginary plane equidistant between the poles of the mitotic spindle
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Microtubule
The thickest of the three main kinds of fibers making up the cytoskeleton of a eukaryotic cell; a straight, hollow tube made of globular proteins called tubulins. Microtubules form the basis of the structure and movement of cilia and flagella
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Mitosis
The division of a single nucleus into two genetically identical daughter nuclei. Mitosis and cytokinesis make up the mitotic (M) phase of the cell cycle
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Mitotic phase (M phase)
The part of the cell cycle when mitosis divides the nucleus and distributes its chromosomes to the daughter nuclei and cytokinesis divides the cytoplasm, producing two daughter cells
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Mitotic spindle
A spindle-shaped structure formed of microtubules and associated proteins that is involved in the movements of chromosomes during mitosis and meiosis. (A spindle is shaped roughly like a football)
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Oncogenes
A cancer causing gene; usually contributes to malignancy by abnormally enhancing the amount or activity of a growth factor made by a cell
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Prometaphase
The second stage of mitosis, during which the nuclear envelope fragments and the spindle microtubules attach to the kinetochores of the sitter chromatids
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Prophase
The first stage of mitosis, during which the chromatin condenses to form structures (sister chromatids) visible with a light microscope and the mitotic spindle begins to form, but the nucleus is still intact
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Proto-oncogenes
A normal gene that can be converted to a cancer-causing gene
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Ras gene family
Family of genes encoding small GTPases that are involved in cellular signal transduction. Activation of Ras signalling causes cell growth, differentiation and survival
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Sarcoma
Cancer of the supportive tissues, such as bone, cartilage, and muscle
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Sexual reproduction
The creation of offspring by the fusion of two haploid sex cells (gametes), forming a diploid zygote
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Sister chromatids
One of the two identical parts of a duplicated chromosome in a eukaryotic cell
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Somatic cell
Any cell in a multicellular organism except a sperm or egg cell or a cell that develops into a sperm or egg
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Spindle apparatus
The structure that separates the chromosomes into the daughter cells during cell division
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Telophase
The fifth and final stage of mitosis, during which daughter nuclei form at the two poles of a cell. Telophase usually occurs together with cytokinesis
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Tumor
An abnormal mass of cells that forms within otherwise normal tissue
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Tumor suppressor gene (P53)
A gene whose product inhibits cell division, thereby preventing uncontrolled cell growth
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Zygote
The fertilized egg, which is diploid, that results from the union of a spree, cell nucleus and an egg cell nucleus
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