Pulmonary Defense Mechanisms--Semester 1 Mini 3

  1. Anti-infammatory cytokines?
    IL-10, TGF Beta
  2. Proinflammatory Cytokines secreated by Epithelial Cells?
    IL1, IL6, TNF alpha, IL 15
  3. Antimicrobial Peptides?
    Beta Defensins

    Small cationic peptides, pokes holes in membrane of microbes


    Small cationic peptides: destablize membranes of microbes
  4. Antimicrobial Proteins?
    • Surfactant Protiens A and D
    • secreted by Type II alveolar cells: permeailization of membranes and opsonization

    • Lysozyme:
    • Muramidase: cleaves gram postive cell walls
  5. How do normal microbiota fight invading microbes?
    • Compete for space, nutrients
    • some produce antibacterial stubstances: lactic acid, H2o2, and bacteriocins
  6. Most common causes of Disease in human?
    Acute Respiratory Tract infection
  7. what is the main secreted Immunoglobulins in mucosal?
    IGA, hooks onto pathogen like a ball and chian, can bind to toxins to neutralize. it interferse with pathogen adhesion

    IGG is used for opsinization
  8. Decribe Mucosal Immunity?
    • Alveolar Macrophages First line of defense
    • phagocytic
    • scretes IL-10 to avoid inflamation
    • resides in lamina propria
    • Represent about 85% of alveloar inflmmatory cell present in bronchalveolar lavage

    Long lived
  9. Describe Macrophages in mucosal immunity killing mechanisms?
    • Phagocytosis SP-A and SP d opsonized pathgens.
    • IGG
    • uses ROSs
    • uses antimicrobial cationic peptides like Beta defensins and cathelicidnins, also uses lysozyme

    can secreate IL8 to recuit neutrophils when too much microbes
Card Set
Pulmonary Defense Mechanisms--Semester 1 Mini 3
Ross U semester 1 Mini 3 Pumonary Defense Mechanisms ( Important concepts)