Metoprolol (Lopressor)

Selective Beta-Blocker

Beta-antagonist that blocks both beta one and beta two adrenergic receptors. Selective for Beta one receptors

Causes reduction in heart rate, systolic blood pressure, and cardiac output following administration because of its selective effects for Beta one adrenergic receptors. Inhibits Tachycardia (Especially after acute MI)

• Onset: Immediate
• Peak: 20 minutes
• Duration: 13-19 hours
• Half-Life: 3-4 hours

Used in pts with suspected or definitive acute MI who are hemodynamically stable, A-Fib, SVT’s not responding to vagal or Adenocard

Heart rate less than 45 BPM, a systolic BP less than 100 mmHg, or CHF, Pt showing early or late signs of shock, hx of asthma or bronchospastic disease, first degree heart block (PR interval greater than .24 sec), second and third degree heart block

• Monitor BP, Pulse, ECG, RR.
• Discontinue use with s/s of CHF, bradycardia, shock, heart block, bronchospasm

• Bradycardia,
• Bronchospasm
• CHF
• Depression
• dyspnea
• Heart Block
• Hypotension
• Lethargy
• Weakness
• Wheezing

Initial bolus 5mg, second IV injection after 2 mins 5 mg(if vitals are stable), third IV injection after 2 mins 5mg (if vitals are stable)

Not indicated

Adult 15 mg

IV/IO

5mg vials