Methylprednisolone (Solu-Medrol)

Corticosteroid

A synthetic steroid with potent anti-inflammatory properties.

Potent anti-inflammatory properties and inhibit many substances that cause inflammation and also inhibit the synthesis of pro-inflammatory enzymes.

• Onset: varies
• Peak: 4-8 days
• Duration: 1-5 weeks (IM)
• Half-Life: 3.5 hours

Serve anaphylaxis, asthma, or COPD, and Urticaria

No major contraindications in the acute management of serve anaphylaxis

Only one dose pre-hospital should be given, Long term therapy can cause GI bleeding, prolonged wound healing, and suppression of adrenocortical steroids

• Abdominal distention
• CHF
• Fluid retention
• Headache
• Hiccups
• Hypertension
• Malaise
• Nausea
• Vertigo

Serve anaphylaxis- 125-250 mg administered IV. Can be given IM but IV is preferred in EMS

30 mg/kg

Pre-hospital is one dose 125-250 mg

IV/IO/IM

Prefilled syringes or vials with 250mg OR 125mg