Diltiazem (Cardizem)

  1. Class:
    Calcium Channel Blocker
  2. Description:
    Calcium channel blocker that causes relaxation of vascular smooth muscle and slows conduction through AV node
  3. Mechanism of Action
    Slows conduction through the atrioventricular mode, causes vasodilation, decreases rate of ventricular response, decreases myocardial oxygen demand
  4. Onset of Action
    • Onset: 3 minutes
    • Peak: 7 minutes
    • Duration: 1-3 hours Half-Life: 2 hours
  5. Indications:
    Control rapid ventricular rates associated with A-Fib and A-Flutter, Angina pectoris, PSVT refractory to adenosine
  6. Contraindications:
    Hypotension, Wide complex tachycardia, conduction system disturbances, cardiogenic shock, Wolff-Parkinson-White Syndrome
  7. Precautions
    Not used in pts receiving IV beta blockers, hypotension, must be kept refrigerated, 30 day self-life if not refrigerated
  8. Side Effects
    • Asystole
    • Bradycardia
    • Dizziness
    • Headache
    • Heart block
    • Hypotension
    • Nausea/vomiting
  9. Adult Dose
    • .25mg/kg bolus (typically 20mg) IV over 2 minutes, followed by maintenance infusion of 5-15mg/hr
    • PSVT: .25mg/kg IV Bolus over 2 minutes
  10. Pedi-Dose:
    Rarely Used
  11. Max Dose:
    One dose in pre-hospital arena Max 25 mg
  12. Routes of Administration
    IV/ IO IV Drip
  13. How Supplied:
    Prefilled syringes and vials containing 25mg Total
Card Set
Diltiazem (Cardizem)
Paramedic Drugs