-
Class:
Antidysrhythmic agent (group III)
-
Description:
First and Second antidysrhythmic used to treat ventricular dysrhythmias
-
Mechanism of Action
- Prolongs action potential and refractory period
- Slows sinus rate; increase PR and QT intervals
- Decrease peripheral vascular resistance
- Potassium Channel Blocker
-
Onset of Action:
- Immediate (IV + IO)
- Duration Varies
- Half-Life: 48 Days (IV/IO Dosing)
-
Indications:
- V-Fib + Pulseless V-tach 300 mg IVP Then after 5 mins give 150 mg
- V-Tach with Pulse 150 mg every 10 mins
- A-Fib, A-Flutter, SVT’S
-
Contraindications:
- Serve sinus node dysfunction
- Sinus bradycardia
- Second and third degree atrioventricular block Hemodynamically significant bradycardia
-
-
Side Effects
Anorexia,hypotention,malaise/fatigue,nausea, Pulmonary toxicity,Tremors Ventricular ectopic beats
-
Side Effects
Hypotension, Nausea, Anorexia, Malaise/fatigue, Tremors, Pulmonary toxicity, Ventricular ectopic beats
-
Adult Dose:
- Loading Dose: 150mg over 10 minutes (15 mg/min)
- Maintenance Dose: 1 mg/min over 6 hours then .5 mg/min until dysrhythmia is controlled or oral therapy begins
- V-Fib- Pulseless V-Tach 300mg IVP then after 5 min give 150 mg
-
Pedi-Dose
5mg/kg IV or IO
-
Max Dose:
- ADULT: 450 mg IV Bolus and/or 2.2g in 24 hours
- PEDI: 15mg/kg
-
Routes of Administration
IV or IO
-
How Supplied:
- 150 mg Vials
- 300 MG Brista-jets
|
|
