Drug Induced Neurological disorder

- black out, lapse in memory, sudden alter of conscious
- falling, shaking, convulsion of all limbs
- jerks, shoulder shrugs
- sterotypical sensation of authomatic uncontrolled movement.

A) seizure
B) peripheral neuropathy
C) delirium
D) movement disorder

what monitor do you use to r/o seizure?

5 different categories of meds that can induce sz. (I)

ALL analgesics cause sz. T or F
True False

list analgesics that cause seizure

what to monitor closely with meperidine for seizure?

which abx cause sz? (mechanism behind it?)

all carbapenem cause sz. so if sz, what to do?

what to check before FQ to minimize sz? what else can you use instead?

which antidepressant can cause sz?

what does anti-depressant induced sz depend on?

which 3 anti-depressant has lowest sz risk?

all anti-depressant induced sz are dose dependent. T or F
True False

what anti-psychotics induce seizure? (I)

which anti-neoplastic meds induce sz? (I)

risk factors for drug induced sz (I).

how to prevent drug induced sz?

drug induced sz produces epilepsy. T or F
True False

what is the focus of tx for drug induced sz? (I)

how to tx acute drug induced sz? (I)

if drug-induced sz is sustained (not acute anymore; multiple sz), what to use?

what does acute onset mean?
subacute?
tardive?
(II)

EPS (extrapyramidal sympt) does NOT include:
A) parkinsonism
B) tardive dyskinisia
C) dystonia
D) akathisia

which neuroleptic is better for movement disorder?
conventional vs. atypical?

which 2 antipsychotics have high risk/dose dependent EPS?

which 2 antipsychotics have mod risk/dose dependent EPS?

which 1 antipsychotic have mod risk/NON-dose dependent EPS?

which 2 antipsychotics have low risk/NON-dose dependent EPS?

which has EPS independent of dose?
A) Invega (paliperidone)
B) Geodon (ziprasidone)
C) Zyprexa (olanzapine)
D) clozapine

which has EPS dependent of dose?
A) Risperdal (risperidone)
B) Seroquel (quetiapine)
C) clozapine
D) Abilify (aripiprazole)

which has high risk of EPS? (this is also dose-dependent)
A) clozapin
B) Geodon
C) Risperdal
D) Abilify

which has moderate risk and NON dose dependent EPS?
A) Abilify
B) Geodon
C) Invega
D) Zyprexa

Which has low risk (non-dose dep) EPS?
A) Seroquel
B) Zyprexa
C) Abilify
D) Invega

subjective: feeling restlessness, need to move
objective: pacing, walking in place, foot/toe tapping, rocking while seated.
distress if unable to move. symptoms during sleep.
what movement disorder is this?

does akathisia subside voluntarily?

which meds cause durg-induced akathisia?

risk factors for drug induced akathisia.

how to manage drug induced akathisia?

abnormal involuntary delayed onset of choreoathetoid sterotypic movements.
non painful, embarrassing
difficulty chewing, swallowing, talking
lipsmacking, chewing movement, tongue protrusion.
which movement disorder is this?

which body parts does tardive dyskinesia affect?

which meds cause tardive dyskinesia?

are the drugs that cause akathisia similar to those that cause tardive dyskinesia? how about incidence-wise?

are the drugs that cause akathisia similar to those that cause dystonia? how about incidence-wise?

risk factors for drug induced TD?

how to manage drug induced TD?

sustained involuntary muscle contractions or spasms resulting in abnormal postures or twisting and repetitive movements.
what movement disorder is this?

difficulty walking, breathing, head turning, speech, swallowing.
what movement disorder is this?

associated with pain, distress, disability.
A) parkinsonism
B) akathisia
C) dystonia
D) tardive dyskinesia

agents in drug induced dystonia.

Drugs that cause dystonia are (same/different) as for akathisia and tardive dyskinesia.

Drugs that cause dystonia have (high/low) incidence as for akathisia and tardive dyskinesia.

risk factors are male and young age.
A) dystonia
B) parkinsonism
C) akathisia
D) tardive dyskinesia

how to manage acute dystonia?

how to manage chronic dystonia?

which body region does dystonia affect?

tremor rigiditiy, slowness of movement affecting bilateral upper and lower extremities and truncal regions.
what movement disorder?

masked facies, micrographia, slow shuffling gait, stooped posture.
what movement disorder?

agents in drug induced parkinsonism?

tetrabenazine is NOT used in this condition b/c it actually induces this.
A) tardive dyskinesia
B) dystonia
C) akathisia
D) parkinsonism

methyldopa, reserpine, valproate cause this.
A) parkinsonism
B) akathisia
C) tardive dyskinesia
D) dystonia

if you have peripheral neuropathy, waht should you r/o first?

if underlying condition is treated, peripheral neuropathy symptoms can improve. t or f
True False

drugs that induce peripheral neuropathy?

risk factors for drug induced peripheral neuropathy

how to prevent drug induced peripheral neuropathy?

isoniazid causes peripheral neuropathy. why does it cause PN and what can you give?

disturbance in consciousness and change in cognition that occurs over a brief period of time.
what condition is this?

what is a lab test for delirium?

mechanisms of drug induced delirium?

what agents can you give to manage drug induced delirium?

agents that cause drug induced depression

risk factor for corticosteroid induced depression.

risk factor for efavirenz induced depression

risk factor for topiramate induced depression.

risk factor of interteron alfa induced depression

risk factor for oral contraceptive induced dpression

how to prevent drug induced depression when using interferon?

how to prevent drug induced depression when using gonadotropin-releasing hormone agonist?

drugs that cause anxiety.

how to manage drug induced anxiety

drug induced psychosis is commonly associated with the alteration of ___ concentration.

onset is slow.
A) dementia
B) psychosis
C) delirium

pattern is stable.
A) delirium
B) psychosis
C) dementia

patient is oriented.
A) psychosis
B) dementia
C) delirium

attention is normal.
A) delirium
B) psychosis
C) dementia

cognition is selectively impaired.
A) delirium
B) psychosis
C) dementia

cognition and attention are disordered.
A) psychosis
B) dementia
C) delirium

speech is incoherent.
A) dementia
B) delirium
C) psychosis

speech is rapidly pressured.
A) psychosis
B) dementia
C) delirium

risk for drug induced psychosis.

what are underlying dz states that worsen drug induced psychosis.

can you use anticholinergic to manage psychosis?

does psychosis go away after d/c drug?

antidote for anticholinergic when psychosis

antidote for opioids when psychosis

antidote for benzo when psychosis