Osteoarthritis

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What are the risk factors for OA?
- Obesity
- Previous occupation
- Certain sports
- Hx of joint trauma
- Genetics
What is the MOA of APAP in OA?

Inhibition of prostaglandins in the CNS
What is the MOA of NSAIDs in OA?

Inhibition of prostaglandins in the periphery by blocking COX
What is the MOA of Glucosamine/Chondroitin in OA?

Stimulates proteoglycan synthesis from cartilage in vitro
What is the MOA of Tramadol in OA

Centrally acting opioid analgesic
What is the MOA of opioids in OA?

Opioid agonism
What is the MOA of capsaicin in OA?

Depletion of substance p from nociceptive nerve fibers
What is the MOA of topical NSAIDs in OA?

blocks local COX-2 in the tissues
What is the MOA of methylsalicylate in OA?

counter irritation
What is the MOA of intra-articular corticosteroids in OA?

Anti-inflammatory
What is the MOA of hyaluronate in OA?

thickens the fluid in the joints
What are the SE of APAP?
- hepatotoxicity
- nephrotoxicity
What are the SE of NSAIDs?
- Nausea
- Abdominal pain
- Diarrhea
- GI bleed
- Nephrotoxicity
- Hepatitis
- Fluid retention
What are the SE of COX2 inhibitors?
- Increased risk of CV events
- Renal disease
What are the SE of glucosamine/chondroitin?
- Gas
- Bloating
- Nausea
What are the SE of tramadol?
- NV
- Constipation
- Somnolence
What are the SE of intra-articular corticosteroids?
- Infection
- Osteonecrosis
- Tendon rupture
What are the SE of opioids?
- NV
- Constipation
- Somnolence
What are the SE of capsaicin?
- Burning
- Stinging
- Erythema
What are the SE of topical NSAIDs?

dermatitis
What are the SE of methylsalicylate?

irritation
What are the SE of hyaluronate?
- Joint swelling
- Rash
- Pruritis
What are the DI of APAP?
- INH
- Warfarin
What are the DI of NSAIDs?
- Li
- Warfarin
- PO hypoglycemics
- Hi-dose MTX
- ACEI
- BBL
- Diuretics
What are the DI of COX2 inhibitors?

CYP450

Author

giddyupp

75139

Card Set

Osteoarthritis

Description

Osteoarthritis

Updated

2011-03-25T06:34:52Z

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