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What type of pathogen is used for live vaccines?
active, but weakened strain of the virus
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What type of pathogen is used for killed/inactivated vaccines?
- Killed virus
- virus fragments
- killed bacteria
- bacterial antigens
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What type of pathogen is used for toxoids?
Inactivated bacterial toxins
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Which type of vaccination is confers the greatest immunity?
live vaccines
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How are live vaccines generally dosed?
- 1-2 doses (1 dose and a booster)
- Only given to those >1 yo d/t possible interference of circulating maternal antibodies
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How are inactivated vaccines generally dosed?
- In a series, 4 wks between shots
- Last dose 6mo after 1st dose or 2nd to last dose
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How are toxoids generally dosed?
- In a series
- Boosters required for life
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How are live vaccines spaced from other vaccines?
- Live vaccines can be given simultaneously, but if they are not, the must be 28d apart
- Separate by at least 1yr from blood products
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What are the SE associated with live vaccines?
milder version of the disease
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What are the SE associated with inactivated vaccines?
generally only mild injection site reactions
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What are the SE associated with toxoids?
More local tissue reactions than other vaccines (most likely d/t adjuvants)
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Which vaccines are live?
- Varicella/Zoster
- MMR
- Smallpox
- Polio (oral)
- LAIV
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Which vaccinations are inactivated?
- Hep A
- Hep B
- Influenza IM
- Meningococcal
- Pertussis
- Polio (injection)
- Pneumococcal
- HPV
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Which vaccinations are toxoids?
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What should you do if a patient has a serious adverse reaction to a vaccine?
Report it to VAERS
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Which vaccines are recommended for the immunocompromised?
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Which vaccines are CI in the immunocompromised?
- MMR
- Varicella
- Zoster
- MMRV
- LAIV
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Which vaccines are recommended in Pregnancy?
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Which vaccines are CI in pregnancy?
- LAIV
- MMR
- Varicella
- Zoster
- MMRV
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Which vaccines are recommended in Asplenia?
- Pneumococcal
- Meningococcal
- Hib
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Which vaccines are recommended for the elderly?
- Zoster
- Pneumococcal
- Influenza
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Which vaccines are scheduled for teens?
- Tdap (11-12)
- HPV (11-12)
- MCV4 (11-12)
- Influenza (yearly)
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How is Tetanus, Diphtheria, Pertussis scheduled for adults?
- Replace one booster with Tdap
- Td q 10y thereafter
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