removes thos lymphocytes that hve receptors for self antigens.
when lymphocyted bind to self antigens, clonal deletion occurs
specificity
the property of the immune system
each reaction is directed towards a specific foreign antigen
diversity
the ability of the immune system to produce different kinds of antibodies and T cell receptors each reacting with a different epitote (antigenic determinant)
memory
it can recognize substances it has previously encountered
which allows the immune system to respond rapidly
(by making memory cells during first reaction)
APC's
antigen presenting cells
macrophages and B cells
--ingest whole microbe or just antigen, process it and place the antigen on it's surface on the major histamine complex (MHC)
Anitgen
some kind of molecule that will elicite some kind of immune responce
epitode
part of the anitgen - determinant site
B cells
come from the bone marrow and differentiate in the bone marrow
T cell
come from the bone marrow but differentiate in the thymus
Humoral
B cell responce to T-dependent anitgen
Humoral
B cell responce to T-independent antigen
antibody -- IgM
pentamer
1st one secreted into blood during the early stages of primary responce
10 antigen binding sites
activates compliment and causes the microorganism to clump together
antibody -- IgA
secretory: two monomers united togther by a J chain
has an attached secretory component which protects it from protein splitting enzymes
binds antigens and microorganisms before they invade the tissue -- also activates compliment
antibody -- IgG
the main class found in the blood
produced in large quantities during secondary responce
only immunoglobulin that can cross the placenta
antigen binding site attaches to antigen on microorganism
tissue binding site attaches to receptors on phagocytic cells
antibodies
all produced by B cells
y-shaped protein molecule
chemical structurs of the constant regions determine the class it belongs to
the variable region have a particular shape and charge that enables the molecule to bind to a particular antigen