-
Interferon beta SE and MAO
- DOC, first line
- they bind to lymphocytes, causes a reduction of the migration of t cells into the cns, reduce proliferation and reduction of cytokine production, fewer macrophages stimulated and less attack on myelin and oligogendrocytes
- suppress the movement of t cells out of circ, generation of cytokines, inflamm that cytokines produce
- SE
- Suppress T cell activity--> high risk of opportunisitic infection
- flu like symptoms
- reduce wbc/rbc
- depression/suicide thoughts
- neutralizing antibodies develop (can lose its effects)
-
Avonex
- interferon- beta DMA
- treatment of MS
-
Rebif
- interferon- beta DMA
- treatment of MS
-
Betaseron
- interferon- beta, DMA
- treatment of MS
-
Glatiramer Acetate
- Copaxonetreatment of MS
- DMA
- similar to myelin based proteins (protein integrated in myelin)
- antibodies now attack this short peptide drug instead of the myelin
- raise levels of helper tcells (helper tcells suppress killer t cells from moving into the cns)
- similar to interferon
- SE
- Sub q qd
- 15mins after admin pt is chest heavy (like mi/angina)
- hard to breathe
- contraindicated in pt w <3 problems
-
Natalizumab
- Tysabri
- treatment of MS
- DMA
- infused monthly
- monoclonal antibody against alpha 4 intergins on tcells
- normally Alpha 4 beta 1 help with cell adhesion with this drug we reduce interaction between alpha beta and vcam1.. impair the interaction.. fewer adhesion/ cells moving into the blood stream
- more efficacious than interferon and copaxone 2x
- they cut clinical trails short because it was so good
- SE
- Progressive Multifocal leukoencephalopathy
- -where a virus rises up and cause encephalitis (suppressing the immune system.. increase virus and bacteria).. taken off the market but put back on bc of how good it was.. pt must seek specific drs for this and monitored carefully
- depression
-
Dalfampridine
- Ampyra
- treatment of MS
- NOT A DMA
- reduces the effects of the demyelination, neurons are still being demyelinated by tcellls
- PO
- K channel blocker, keeps K in the neuron (improves neuronal conduction)
- dont see less unmylenated, or plaques but see improvements of symps.. muscle strength/movement and walking (doesnt improve vision and speech)
- SE
- Seizures (cells more depolarized)
- UTI
-
Fingolimod
- Gilenya
- treatment of MS
- DMA and PO
- upon admin it gets phosphorylated
- agonist at the S1P1 (help tcells move out of the lymphocytes and thymus) receptor, desensitize it, now they cant respond to S1P.. Tcells wont move out of the thymus or lymph nodes.. reduction of tcells in circ
- SE
- first dose phenomenon (bradycardia.. decrease HR.. has nothing to do with the vessels like in alpha 1 antag)
- S1P is found throughout the body (smooth and cardiac muscle)
- LONG TERM SE
- hypertension, Seizures, swelling of retina, inflam bronchial, URTI
-
Mitoxantrone
- Novantrone
- treatment of seconday MS
- anticancer drug, kills killer tcells
- antineoplastic drug, not used for relapsing remitting MS
- SE
- dose related cumulative cardiotoxicity (irreversible).. based on body SA.. bc of heart size
-
Cyclosporine
- Sandimmune, Neoral, Restasis
- Immunosuppressants
- interacts w cyclophilin= inhibits calcineurin --> less dephosphorylation of nfat= less nfat in nucelus for t cell proliferation
- met by 3A4.. many DI
- ADR
- hypertention, nephrotoxic, cholesterol, hiritisum, gingival hyperplasia
-
Tacrolimus
- Prograf, Protoptic (cream)
- Immunosuppressants
- calcineurin inhib- binds to FKBP
- ADR
- hypertension, nephrotoxic, hyperglycemia, seizures
-
Pimecrolimus
- Elidel cream
- Immunosuppressants
- calcineurin inhib
-
Sirolimus
- Rapamune
- Immunosuppressants
-
-
Mycophenolate mofetil
- Cellcept, Myfortic
- Immunosuppressants
-
Daclizumab
Immunosuppressants
-
Basiliximab
Immunosuppressants
-
Muromonab-CD3
Immunosuppressants
-
Methotrexate
Traditional DMARDs
-
-
Sulfasalazine
Traditional DMARDs
-
Hydroxychloroquine
- Plaquenil
- Traditional DMARDs
-
Gold
- Auranofin, solganol
- Traditional DMARDs
-
Penicillamine
Traditional DMARDs
-
-
Cyclosporine
Traditional DMARDs
-
Enbrel
- etanercept
- Biological DMARDs
-
Remicade
- Infliximab
- Biological DMARDs
-
Humira
- Adalimumab
- Biological DMARDs
-
Cimzia
- Certolizumab
- Biological DMARDs
-
Simponi
- Golimumab
- Biological DMARDs
-
Kineret
- Anakinra
- Biological DMARDs
-
Actemra
- Tocilizumab
- Biological DMARDs
-
Orencia
- Abatacept
- Biological DMARDs
-
-
Olsalazine
- Dipentum
- IBD
- Aminosalicylates, 2nd gen
-
Balsalazide
- Colazal
- IBD
- Aminosalicylates, 2nd gen
-
Mesalamine
- Asacol, Pentasa, Rowasa, Canasa
- IBD
- 5-Aminosalicylates
-
Budesonide
- Entocort EC
- IBD
- Corticosteroids
-
-
-
-
-
-
-
Estradiol
- Estrace, Climara, Vivelle
- Estrogen receptor agonist for HRT
-
Estrone/ estropiprate
- Ogen
- Estrogen receptor agonist for HRT
-
Conjugated estrogens
- Premarin
- Estrogen receptor agonist for HRT
-
Esterified estrogens
- Menest
- Estrogen receptor agonist for HRT
-
Synthetic Conjugated estrogens
- Cenestin, Enjuvia
- Estrogen receptor agonist for HRT
-
Estrogen
- Vagifem, Estring, Femring
- Estrogen receptor agonist for HRT
-
Raloxifene
- Evista
- Selective Estrogen Receptor Modulators
-
Tamoxifen
- Nolvadex
- Selective Estrogen Receptor Modulators
-
Toremifene
- Fareston
- Selective Estrogen Receptor Modulators
-
Fluvestrant
- Faslodex
- SERD
- Selective Estrogen Receptor Modulators
-
Medroxyprogesterone acetate
- Provera
- Progestin receptor agonist for HRT
-
Norethindrone
- Aygestin
- Progestin receptor agonist for HRT
-
Progesterone
- Prometrium, Crinone
- Progestin receptor agonist for HRT
-
Prempro
- Combinations of estrogens and progestin
- Progestin receptor agonist for HRT
-
Femhrt
- Combinations of estrogens and progestin
- Progestin receptor agonist for HRT
-
Climara Pro
- Combinations of estrogens and progestin
- Progestin receptor agonist for HRT
-
Combipatch
- Combinations of estrogens and progestin
- Progestin receptor agonist for HRT
-
Ethinyl estradiol
Estrogen in contraceptves
-
Mestranol
Estrogen in contraceptves
-
Medroxyprogesterone
Progestin in contraceptves
-
Norgestrel
Progestins in contraceptives
-
Levonorgestrel
- Plan B
- Progestin in contraceptves
-
Norethindrone
Progestin in contraceptves
-
ethynodiol
Progestin in contraceptives
-
norgestimate
Progestin in contraceptives
-
Desogestrel
Progestin in contraceptives
-
Drosperinone
Progestin in contraceptives
-
Mifepristone
- RU-486
- Progesterone receptor antagonist
-
Clomiphene
- Clomid
- Estrogen receptor antagonist
-
FSH
- Gonadotropins
- Recombinant or purified
-
LH
- Gonadotropins
- Recombinant or purified
-
hcg
- Gonadotropins
- Recombinant or purified
-
Menotropins
Gonadotropins
-
Gonadorelin
- synthetic GnRH
- Gonadotropins
-
Ganirelix
GnRH receptor antagonist
-
Cetrorelix
GnRH receptor antagonist
-
Testosterone
- Depo testosterone, Androderm patch, androgel, Testim
- Androgen
-
Methyltestosterone
Androgen
-
-
Fluoxymesterone
- Halotestin
- Anabolic steroids
-
Oxandrolone
Anabolic steroids
-
Oxymetholone
Anabolic steroids
-
Stanozolol
- Winstrol
- Anabolic steroids
-
Nandrolone
- Deca Durabolin
- Anabolic steroids
-
Abarelix
GnRH receptor antagonist
-
Leuprolide
- Lupron
- GnRH receptor agonists
-
Nafarelin
GnRH receptor agonists
-
Goserelin
GnRH receptor agonists
-
Buserelin
GnRH receptor agonists
-
Histrelin
GnRH receptor agonists
-
Triptorelin
GnRH receptor agonists
-
Finasteride
- Propecia, Proscar
- 5-alpha reductase inhibitors
-
Duasteride
- Avodart
- 5-alpha reductase inhibitors
-
Flutamide
- Androgen receptor antagonists
- Eulexin
-
Bicalutamide
- Casodex
- Androgen receptor antagonists
-
Nilutamide
- Androgen receptor antagonists
- Nilandron
-
Human recombinant Growth Hormones
- Somatropins, Somatrem
- Growth hormones
-
Sermorelin
Growth hormones
-
Recombinant human IGF-1
Growth hormones
-
Octreotide
- Sandostatin
- Growth hormones
-
-
Estrogens
- Anti-resorptivedrugs
- Osteoporosis
-
Raloxifene
- Anti-resorptivedrugs
- Osteoporosis
-
Bisphosphonates
- Anti-resorptivedrugs
- Osteoporosis
-
Calcitonin
- Anti-resorptivedrugs
- Osteoporosis
-
Calcium
- Anti-resorptivedrugs
- Osteoporosis
-
Vitamin D
- cholecalciferol(D3), ergocalciferol(D2), calcitriol
- Anti-resorptivedrugs
- Osteoporosis
-
Teriparatide
- Forteo
- Anabolic
- osteoporosis
-
Lispro
- Humalog
- Rapid acting insulin
-
Aspart
- Novolog
- Rapid acting insulin
-
Glulisine
- Apidra
- Rapid acting insulin
-
HumulinR, NovolinR
Regular Short acting insulin
-
HumulinN, NovolinN
- intermediate acting insulin
- NPH
-
Glargine
- Lantus
- Long acting insulin
-
Detemir
- Levemir
- Long acting insulin
-
-
-
Rosiglitazone
- Avandia
- thiazolidinediones
- Diabetes
-
Pioglitazone
- Actos
- thiazolidinediones
- Diabetes
-
Acarbose
- Precose
- alpha-glucosidase inhibitors
- diabetes
-
Miglitol
- Glyset
- alpha-glucosidase inhibitors
- Diabetes
-
Chlorpropamide
- insulin secretagogues
- Sulfonylureas
- Diabetes
-
Glyburide
- Micronase
- insulin secretagogues
- Sulfonylureas
- Diabetes
-
Glimpepiride
- Amaryl
- insulin secretagogues
- Sulfonylureas
- Diabetes
-
Repaglinide
- Prandin
- insulin secretagogues
- Meglitinides
- Diabetes
-
Nateglinide
- Starlix
- insulin secretagogues
- Meglitinides
- Diabetes
-
Exenatide
- Byetta
- insulin secretagogues
- GLP-1 receptor agonists
- Diabetes
-
Liraglutide
- Victoza
- insulin secretagogues
- GLP-1 receptor agonists
- Diabetes
-
Sitagliptin
- Januviainsulin secretagogues
- DPP-IV inhibitors
- Diabetes
-
Saxagliptin
- Onglyza
- insulin secretagogues
- DPP-IV inhibitors
- Diabetes
-
Levothyroxine
- Synthroid, Levoxyl, Levothroid, Unithroid
- Thyroid hormone preparations
- T4
-
Liothyronine
- Cytomel
- Thyroid hormone preparations
- T3
-
Liotrix
- Thyrolar
- Thyroid hormone preparations
- T3+T4
-
Desicated Thyroid
Thyroid hormone preparations
-
-
-
Thiocyanate
- ionic inhibitors
- antithyroid
-
Perchlorate
- ionic inhibitors
- antithyroid
-
Lugol's solution
Iodide, antithyroid
-
-
-
Prochlorperazine
- Compazine
- D2 receptor antagonist
- Anti-emetics
-
Trimethobenzamide
- Tigan
- D2 receptor antagonist
- Anti-emetics
-
Promethazine
- Phenergan
- D2 receptor antagonist
- Anti-emetics
-
Ondansetron
- Zofran
- 5-HT3 receptor antagonist
- Anti-emetics
-
Granisetron
- Kytril
- 5-HT3 receptor antagonist
- Anti-emetics
-
Dolasetron
- Anzemet
- 5-HT3 receptor antagonist
- Anti-emetics
-
Palonosetron
- Aloxi
- 5-HT3 receptor antagonist
- Anti-emetics
-
-
-
Aprepitant/ Fosaprepitant
- Emend
- NK-1 receptor antagonist
- Anti-emetics
-
Dronabinol
- Marinol
- CB-1 receptor agonist
- Anti-emetics
-
Nabilone
- Cesamet
- CB-1 receptor agonist
- Anti-emetics
-
Alosetron
- Lotronex
- Irritable bowle syndrome
-
Lubiprostone
- Amitiza
- Irritable bowle syndrome
-
Misoprostol
- Cytotec
- PGE2 receptor agonist
- anti-ulcer
-
-
Cimetidine
- Tagamet
- H2 receptor antagonist
- anti-ulcer
-
Ranitidine
- Zantac
- H2 receptor antagonist
- anti-ulcer
-
Nizatidine
- Axid
- H2 receptor antagonist
- anti-ulcer
-
Famotidine
- Pepcid
- H2 receptor antagonist
- anti-ulcer
-
Omeprazole
- Prilosec/ Zegerid
- Proton pump inhibitors
- Anti-ulcers
-
Esomeprazole
- Nexium
- Proton pump inhibitors
- Anti-ulcers
-
Lansoprazole
- Prevacid
- Proton pump inhibitors
- Anti-ulcers
-
Dexlansoprazole
- Kapidex
- Proton pump inhibitors
- Anti-ulcers
-
Rabeprazole
- Aciphex
- Proton pump inhibitors
- Anti-ulcers
-
Pantoprazole
- Protonix
- Proton pump inhibitors
- Anti-ulcers
-
Xolair
- Omalizumab
- Anti-IgE therapy
- Drugs that interfere with the hypersensitivity reaction
-
Cromolyn
- Mast cell stabilizers
- Drugs that interfere with the hypersensitivity reaction
-
Nedocromil
- Mast cell stabilizers
- Drugs that interfere with the hypersensitivity reaction
-
Epinephrine
- Drugs that interfere with the hypersensitivity
- reaction
-
Diphenhydramine
- Benadryl
- First generation
- H-1 receptor antagonist (anti-histamines)
-
Clemastine
- Tavist
- First generation
- H-1 receptor antagonist (anti-histamines)
-
Dimenhydrinate
- Dramamine
- First generation
- H-1 receptor antagonist (anti-histamines)
-
Chlorpheniramine
- Chlor-Trimeton
- First generation
- H-1 receptor antagonist (anti-histamines)
-
Brompheniramine
- First generation
- H-1 receptor antagonist (anti-histamines)
-
Hydroxyzine
- Atarax/Vistaril
- First generation
- H-1 receptor antagonist (anti-histamines)
-
Cyclizine
- First generation
- H-1 receptor antagonist (anti-histamines)
-
Meclizine
- Antivert
- First generation
- H-1 receptor antagonist (anti-histamines)
-
Promethazine
- Phenergan
- First generation
- H-1 receptor antagonist (anti-histamines)
-
Cyproheptadine
- Periactin
- First generation
- H-1 receptor antagonist (anti-histamines)
-
Doxepin
- First generation
- H-1 receptor antagonist (anti-histamines)
-
Loratidine
- Claritin
- second generation
- H-1 receptor antagonist (anti-histamines)
-
Desloratidine
- Clarinex
- second generation
- H-1 receptor antagonist (anti-histamines)
-
Cetirizine
- Zyrtec
- second generation
- H-1 receptor antagonist (anti-histamines)
-
Azelastine
- Astelin
- second generation
- H-1 receptor antagonist (anti-histamines)
-
Fexofenadine
- Allegra
- second generation
- H-1 receptor antagonist (anti-histamines)
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