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Host
Any organism that harbors anothers organism.
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Pathegen
An organism capable of causing disease in hour.
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symbiosis
An association between two (or more) species.
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parasitism
one organism (parasite) benefits from the relationship
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mutualism
both members of the association living together benefit from the relationship.
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Commensalism
two species live together in a relationship such that one benefits the other neither benefits nor is harmed.
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Contamination
Micro organisms are present.
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Infection
pathogenic microorganisms penetrate the host defense
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Disease
when an infection alters or changes the state of health from the normal state.
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Pathogenicity
the capacity to produce disease.
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Virulence
refers to the intensity of the diesease
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attenuation
the weakening of the disease-producing ability of the pathogen.
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Resident Microflora
comprise microbes that are always present on or in the human body.
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Transient Microflora
Microbes that can be present under certain environmental conditions in any of the locations where resident microflora are found.
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Opportunistic pathogen
Organisms that take advantage of particular opportunities to cause disease.
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Conditions that create opportunities for opportunistic organisms include
- failure of the host's normal defenses.
- Introduction of the organism into unusual body sites.
- Disturbances in the normal microflora.
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Microbial antagonism
Normal microflora competeing with pathogenic organisms and in some instances actively combating their growth.
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Infectious Disease
caused by infectious agents such as bacteria, viruses, fungi, protozoa, and helminths.
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Noninfectious Disease.
caused by any factor other than infectious organisms.
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Toxin
In any substance that is poisonous to other organisms.
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Toxemia
spreading of exotoxins by blood from the site of infection.
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Intoxication
Diseases that result form the ingestion of a toxin.
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Exotoxin
Soluble substances secreted into host tissues.
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Endotoxin
part of the cell wall and are released into host tissues - sometimes in large quantities - from Gram-neg bacteria, ofeten when the bacteria die or divide.
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Symbiosis
an association between two (or more) species. Living together encompasses a spectrum of relationships.
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Recognize examples of each type of symbiosis
- Mutualism.
- Parasitism.
- Commensalism.
- Antagonism.
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How do we become colonized with bacteria?
- Passage thru birth canal.
- contact with others.
- contact with feeding material.
- contact with instruments.
- during nursing.
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location of Staphylococus epdiermidis
- skin.
- mouth.
- Nasopharynx.
- Intestines.
- Urogenital.
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Location of Streptococcus mutans
Mouth.
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Location of Streptococcus pneumoniae
Nasopharynx
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Location of Neisseria meningitidis
Nasopharynx
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Locaiton of Haemophilus influenzae
NasoPharynx
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Location of Lactobacillus species
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List Koch's Postulates
- Agent must be observed in every case of a disease.
- Isolate agent from a disease host and grow in pur culture.
- Agent from pure culture must cause same disease when inoculated into healthy host.
- Agent must be recoerd form the experimentally inoculated host and ID as being identical to the orginal microbe.
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Why are they koch's postulates used?
to be satisfied in order to prove that a specific organsm is the caustice agent of a particular disease.
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How many classifications of diseases
Ten.
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Inherited Diseases
due to errors in genetic information (non-infectious cause)
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Congenital Disease
are structural and functional defects present at birth (due to drugs, xray exposure)
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Degenerative Diseases
are disorders that develop as aging occurs.
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Nutritional Deficiency Diseases
lower resistance to infectious diseases and contribute to the severity of infections.
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Endocrine Diseases
are due to excesses or dificiencies of hormones
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Mental Diseases
Can be caused by a variety of factors (emotional, psychogenic or infection)
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Immunological Diseases
such as allergies, autoimmune diseases, and immunodeficienceies
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Neoplastic Diseases
involved abnormal cell growth that leads to benign or cancerous tumors.
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Iatrogenic Diseases
- are caused by medical procedures and/or treatment.
- Surgical errors.
- nosocomial infections.
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Idiopathic Diseases
are diseases whose cause is unknown.
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How are communicable diseases acquired?
- transmitted from host to host directly or indirectly.
- Direct contact.
- some infections are more easily spread than others.
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How are Non-communicable diseases acquired?
- diseases that are not spread from one host to another.
- acquired from one's own flora (pneumonia).
- acquired form a non-living environmental reservior (tetanus).
- Malaria.
- Food poisoning.
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What are virulence factors?
structural or physiological characteristics that help organisms cause infection and disease.
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How do bacteria adhere to other cells?
- critical point in production of disease.
- adhesins are proteins found on attachment pili (fimbriae) and capsules.
- Adhesins allow pathogen to bind to receptors on target cells.
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List three exoenzymes
- Hyaluronidase.
- Coagulase.
- Streptokinase.
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What are the functions of Streptokinase.
- dissolves blood clots.
- expedites invasion into tissues.
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What are the functions of Coagulase
- triggers blood plasma clotting.
- allowing bacteria protection form immune defenses.
- (Staphylococcus aureus)
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What are the functions of Hyaluronidase?
enzyme digests hyaluronic acid, a glue-like substance that helps hold the cells of certain tissues together. (streptococcus pyogenes)
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List the classic stages of infection.
- 1. Incubation period.
- 2. Prodromal phase.
- 3. Invasive.
- 4. Decline.
- 5. Convalescence.
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What happens to Incubation Period?
- Microbes don't instantly produce symptoms when they enter the body.
- There is a lag between infection and symptoms.
- How Long depends on the organism, the host's response, the infectous dose by what route the organisms entered the body.
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What happens in the Prodromal Phase?
Patients feels well (may have mild symptoms) but may be infectious.
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What happens in Invasive stage?
- Patient experiences typical signs and systems.
- Organism is multiplying becomes well established.
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What happens in Decline Stage?
Symptoms begin to subside.
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What happens in Convalescence Stage?
patient begins to heal may still be infectious to others.
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