What are the indications associated with enoxaparin?
Thromboembolic events (treatment and prophylaxis of DVT).
What is unique about the structure of enoxaparin as compared to heprain's?
Enoxaparin is a fraction of the size of heparin, ranging roughly less than 15 sugar monomers (MW 5000 D).
How is enoxaparin administered?
SubQ.
It can therefore be given on an outpatient basis.
What is enoxaparin's target MOA?
Catalytic potentiation of antithrombin-dependent deactivation of factor Xa.
True or false?
Like heparin, enoxaparin binds with thrombin.
False.
Enoxaparin, as a LMWH, is not larget enough of a molecule to bind thrombin along with antithrombin. It can, however, bind the relatively smaller factor Xa w/ antithrombin.
As per enoxaparin's MOA, what effect is experienced by the body's tissues?
Though it cannot deactivate thrombin directly, deactivation of factor Xa ultimately prevents the conversion of prothrombin to thrombin.
What are some adverse effects associated with enoxaparin?
Thrombosis (as antithrombin is used up).
What drug may be given as an antidote to enoxaparin overdose?
Protamine sulfate.
True or false?
Thrombocytopenia can be somewhat avoided with the use of enoxaparin.
True.
What lab parameters are used to monitor the efficacy/toxicity of enoxaparin?
Anti-Xa assay.
True or false?
Enoxaparin, unlike heparin, may be self-administered.