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When a defect in endothelial lining occurs, what serves as a binding site for the initial platelet?
Exposed collagen.
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What agents are secreted by the initial platelet in the formation of a clot that stimulates further platelet activation?
- ADP
- TXA2 (a prostaglandin product via COX)
- 5HT (aka serotonin)
- Thrombin (aka factor IIa)
- Deceased cAMP
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What agent is secreted by the initial platelet in the formation of a clot that stimulates the coagulation cascade?
Tissue factor, which combines with clotting factor VII to form an active complex.
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What else does COX produce that works to inhibit clotting?
PGI2 (a prostacyclin).
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What is the end product of the coagulation cascade (of clotting factors)? What does this product do?
- Fibrin (via fibrinogen that is converted by activated thrombin IIa).
- Fibrin links platelets at their GP IIb/IIIa sites.
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True or false?
Active thrombin potentiates itself.
True.
Thrombin activates platelets, as well as factors V, VIII, XI, XIII
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True or false?
The complexes formed from the clotting factors of the coagulation cascade may result in amplification of the entire cascade.
True.
Each complex behaves catalytically. That is, each activated complex may result in the activation of many subsequent factors.
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Which activated complex converts prothrombin into active thrombin (IIa)?
Activated clotting factor X (Xa).
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According to Dr. Tarloff, which clotting factors are inhibited by oral anticoagulant drugs?
II, VII, IX, X
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According to Dr. Tarloff, which clotting factors are inhibited by heparin?
Activated IX (IXa), activated X (Xa), and activated II (IIa - thrombin).
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Which clotting factors are down-regulated by protein C?
Activated VIII (VIIIa) and activated V (Va).
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