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Infectious Disease
Illness caused by infestation of the body by biological organisms
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Index Case
The individual who first introduced the infectious agent into a population
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Normal Flora
Organisms that live inside our bodies without ordinarily causing disease
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Pathogen
Organism capable of causing disease
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What are some major public health agencies?
- U.S. Department of Human Health Services (DHHS), Centers for Disease Control (CDC), National Institute for Occupational Safety and Health (NIOSH)
- Federal Emergency Management Agency (FEMA), National Fire Protection Agency (NFPA)
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Opportunistic Pathogen
Ordinarily nonharmful bacterium that causes disease only under unusual circumstances
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Bacteria
Microscopic single-celled organisms that range in length from 1 to 20 micrometers
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Gram Stain
Method of differentiating types of bacteria according to their reaction to a chemical stain process
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Types of Bacteria
- -Spheres (Cocci)
- -Rods
- -Spirals
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Exotoxin
Toxic waste products released by living bacteria
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Endotoxin
Toxic products released when bacteria die and decompose
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Bactericidal
Capable of killing bacteria
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Bacteriostatic
Capable of inhibiting bacterial growth or reproduction
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Virus
Disease-causing organism that can be seen only with an electron microscope
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Obligate intracellular parasite
Organism that can grow and reproduce only within a host cell
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Prions
Particles of protein, folded in such a way that protease enzymes cannot act on them
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Fungus
Plantlike microorganism. Rarely causes negative effects in humans
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Protozoan
Single-celled parasitic organism with flexible membranes and the ability to move
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Parasite
Organism that lives in or on another organism
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Pinworm
Parasite that is 3 to 10 mm long and lives in the distal colon
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Hookworm
Parasite that attaches to the host's intestinal lining
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Trichinosis
Disease resulting from an infestation of Trichinella spiralis
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Reservoir
Any living creature or environment (water,soil, etc.) that can harbor an infectious agent
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Bloodborne
Transmitted by contact with blood or body fluids
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Airborne
Transmitted through the air by droplets or particles
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Fecal-oral Route
Transmission of organisms picked up from the gastrointestinal tract into the mouth
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Communicable
Capable of being transmitted to another host
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Contamination
Prescence of an agent only on the surface of the host without penetrating it
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Infection
Prescence of an agent within the host, without necessarily causing disease
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Factors affecting disease transmission
- -Mode of entry
- -Virulence
- -Number of organisms transmitted
- -Host resistance
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Virulence
An organism's strength or ability to infect or overcome the body's defenses
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Resistance
A host's ability to fight off infection
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Latent Period
Time when a host cannot transmit an infectious agent to someone else
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Communicable Period
Time when a host can transmit an infectious agent to someone else
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Incubation Period
Time between a host's exposure to infectious agent and the appearance of symptoms
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Antigen
Surface protein on most viruses and bacteria that identify then as self or nonself
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Antibody
Protein that is produced in response to and that attacks a disease antigen
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Seroconversion
Creation of antibodies after exposure to a disease
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Window Phase
Time between exposure to a disease and seroconversion
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Disease Period
The duration from the onset of signs and symptoms of disease until resolution of symptoms or death
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Immune System
The body's mechanism for defending against foreign invaders
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Reticuoloenothelial System
The cells involved in the immune response
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Leukocyte
White blood cell
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Neutrophil
The most common phagocytic white blood cell
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Macrophage
After neutrophils, the most common phagocytic white blood cell
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Phagocytosis
Process in which certain white blood cells ingest invaders
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Cell-mediated immunity
Generalized, temporary defense against any invader
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Humoral Immunity
Specialized, permanent defense against a particular foreign antigen
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Lymphocyte
Cell that attacks invader in immune response
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T lymphocytes
Cells that attack invaders in cell-mediated immune responses
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B lymphocytes
Cells that attack invaders in humoral immune responses
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Classes of Human Antibody
- IgG: Remembers antigen and recognizes repeat invasions. Principle immunoglobulin in immune response.
- IgM: Formed early in most immune response.
- IgA: Is the main immunoglobulin in exocrine secretions (milk, respiratory, saliva, tears)
- IgD: Is present on the surface of B lymphocytes, acts as an antigen receptor.
- IgE: Attaches to mast cells in the respiratory and intestinal tracts. It plays a major role in allergic reactions. Patients with allergies generally have increased levels of this immunoglobulin.
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Autoimmunity
The body's formation of antibodies against itself.
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Lymphatic System
Secondary circulatory system that collects overflow fluid from the tissue space and filters it before returning it to the circulatory system.
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Lymph
Overflow circulatory fluid in spaces between tissues.
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Passive Immunity
Newborn's protection against disease that results from the mother's transferring some of her antibodies to the fetus.
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Active Immunity
Protection against disease developed after birth as a result of a direct exposure to the disease.
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Phases of prehospital infection control
- -Preparation for response
- -Response
- -Patient contact
- -Recovery
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PPD
Purified protein derivative, the substance used in a test for tuberculosis.
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Decontaminate
To destroy or remove pathogens
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Decontamination Levels
- -Low-level disinfection
- -Intermediate level disinfection
- -High-level disinfection
- -Sterilization
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Disinfection
To destroy certain forms of microorganisms but not all
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Sterilize
To destroy all microorganisms
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Ryan White Act
Federal law that outlines the rights and responsibilities of agencies and health care workers when an infectious disease exposure occurs
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Diseases of immediate concern
- -HIV
- -Hepatitis
- -Tuberculosis
- -Pneumonia
- -SARS
- -Chickenpox
- -Meningitis
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Human Immunodeficiency Virus
Organism respnsible for acquired immunodeficiency syndrome (AIDS)
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Hepatitis
Inflammation of the liver characterized by diffuse or patchy tissue necrosis. Types: A,B,C, D, E, G.
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Tuberculosis
Disease caused by bacterium known as Mycobacterium tuberculosis that primarily affects the respiratory system
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Respirator
An apparatus worn that cleanses or qualifies the air
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Mask
A device for protecting the face
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Pneumonia
Acute infection of the lung including alveolar spaces and interstitial tissue
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Severe Acute Respiratory Syndrome (SARS)
A highly infectious viral respiratory illness that first appeared in Southern China in 2002
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Varicella
Viral disease characterized by a rase of fluid-filled vesicles that rupture forming small ulcers that eventually scab. AKA chickenpox
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Meningitis
Inflammation of the meninges, usually caused by infection
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Brudzinski's Sign
Physical exam finding in which flexion of the neck causes flexion of the hips and knees. Suggestive of Meningitis
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Kernig's Sign
Inability to full extend the knees with hips flexed. Suggestive of Meningitis
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Influenza
Disease caused by a group of viruses
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Other job-related airborne diseases
- -Influenza and the common cold
- -Measles
- -Mumps
- -Rubella
- -Respiratory Syncytial virus
- -Pertussis
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Measles
Highly contagious, acute viral disease characterized by a reddish rash that appears on the fourth or fifth day of illness
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Mumps
Acute viral disease characterized by painful enlargement of the salivary glands
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Rubella (German-measles)
Systemic viral disease characterized by a fine pink rash that appears on the face, trunk and extremities. Fades quickly
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Respiratory Syncytial Virus (RSV)
Common cause of pneumonia and bronchiolitis in children
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Pertussis (Whooping Cough)
- Disease characterized by severe violent coughing.
- Phases:
- -Catarrhal
- -Paroxysmal
- -Convalescent
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Viral diseases transmitted by contact
- -Mononucleosis
- -Herpes simplex virus type 1
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Monocucleosis
Acute disease caused by the Epstein-barr virus
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Herpes simplex virus
Organism that causes infections characterized by fluid-filled vesicles, usually in the oral cavity or on the genitals
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Other infectious respiratory conditions
- -Epiglottitis
- -Croup
- -Pharyngitis
- -Sinusitis
- -Hantavirus
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Epiglottitis
Infection causing inflammation of the epiglottis
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Croup
Viral illness characterized by inspiratory and expiratory stridor and a seal barklike cough
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Pharyngitis
Infection of the pharynx and tonsils
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Sinusitis
Inflammation of the paranasal sinuses
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Hantavirus
Family of viruses that are carried by the deer mouse and transmitted by ticks and other arthropods
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GI System infections
- -Gastroenteritis
- -Food poisoning
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Gastroenteritis
Generalized disorder involving nausea, vomitting, gastrointestinal cramping or discomfort and diarrhea
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Food Poisoning
Nonspecific term often applied to gastroenteritis that occurs suddenly and that is caused by the ingestion of food containing preformed toxins
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Nervous System infections
- -Encephalitis
- -Rabies
- -Tetanus
- -Lyme disease
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Encephalitis
Acute infection of the brain, usually caused by virus
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Rabies
Viral disorder that affects the nervous system
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Tetanus
Acute bacterial infection of the central nervous system
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Lyme Disease
- Recurrent inflammatory disorder caused by tick-borne spirochete.
- Stages:
- -Early localized
- -Early disseminated
- -Late
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Sexually Transmitted Disease (STD)
- Illness commonly transmitted through sexual contact
- -Gonorrhea
- -Syphillis
- -Genital warts
- -Herpes simplex type 2
- -Chlamydia
- -Trichomoniasis
- -Chancroid
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Gonorrhea
Sexually transmitted disease caused by a gram-negative bacterium
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Syphillis
- Bloodborne sexually transmitted disease caused by spirochete treponema pallidum
- Stages:
- -Primary
- -Secondary
- -Latent
- -Tertiary
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Genital Warts
Warts occuring in the genital area caused by the human papillomavirus (HPV)
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Chlamydia
Group of intracellular parasites that cause STDs
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Trichomoniasis
Sexually transmitted disease caused by the protozoan Trichomonas vaginalis
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Chrancoid
Highly contagious sexually transmitted ulcer
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Impetigo
Infection of the skin caused by staphylococci or streptococci
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Lice
Parasitic infection of the skin of the scalp, trunk or pubic area
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Infestation
Presence of parasites that do not break the host's skin
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Scabies
Skin disease by mite infestation and characterized by intense itching
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Nosocomial
Acquired while in the hospital
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