Procainamide

To which class of drugs does procainamide belong?

Na+ channel blockers (Class 1A).
What indications are associated with procainamide?

Arrhythmia - ventricular tachycardia
What is procainamide's target MOA?

By blocking Na+ channels, the action potentials of the SA node and ventricular myocytes are prolonged (slowed upstroke of action potential).
True or false?

Procainamide is metabolized to an inactive form, NAPA.

False.

Although NAPA is less potent than the parent drug, it still exerts class III antiarrhythmic effects.
As per procainamide's target MOA, what are it's tissue effects?
- 1.) Decreased ventricular excitability w/ increased refractory period.
- 2.) Decreased conduction velocity in atria, His-purkinje system, and ventricles.
- 3.) Decreased abnormal automaticity.
- 4.) Local anesthetic action.
True or false?

Procainamide exerts significant effects on both the SA and AV nodes.

False.

Procainamide has little effects on the SA node.
What are some adverse effects associated with procainamide?
- Lupus-like syndrome (a good reason to d/c).
- Hypotension.
- AV block.
- Ventricular tachyarrhythmias.
- Weak anticholinergic effects.
- CYP2D6 substrate.

Author

jdonaldson

73917

Card Set

Procainamide

Description

Why even bother at this point?

Updated

2011-03-20T00:29:30Z