1. To what drug class does gemfibrozil belong?
    • "Fibrates" -
    • Fibric acid antilipemics
    • PPAR-alpha antagonists
  2. What is PPAR-alpha?
    A nuclear transcription factor.
  3. True or false?

    The active site of gemfibrozil's chemical structure resembles a fatty acid.
  4. What are the indications associated with gemfibrozil?
    Types IV and V hyperlipidemia
  5. True or false?

    Gemfibrozil is more effective than statins, and the statins tend to be add-ons or alternative therapies to the fibrates.

    Fibrates are typically alternatives or add-ons to the statins.
  6. What is gemfibrozil's target MOA?
    • Activates (agonist) PPAR-alpha and PPREs
    • Mimics free fatty acids
  7. Where is PPAR-alpha expressed in the body?
    • Hepatocytes
    • Skeletal muscle
    • Macrophages
    • Heart
  8. How does gemfibrozil's MOA lead to decreased triglycerides in the body?
    • Increased muscle cell expression of LPL
    • Increased uptake of triglyceride rich lipoproteins
    • Decreased hepatic expression of ApoC-III (inhibitor of LPL)
    • Increased transcription of apoA-I and II (HDL apolipoproteins)
  9. Type IV hyperlipidemia is characterized by?
    Type V?
    • IV: hypertriglyceridemia
    • V: high VLDL and chylomicrons
  10. What are some adverse effects associated with gemfibrozil?
    • GI discomfort (most common)
    • Gallstone formation (with older drugs from class)
    • Myopathy
    • Arrhythmia
  11. The three overall outcomes from activation of PPAR-alpha by gemfibrozil are...
    • 1.) Increased plasma HDL
    • 2.) Decreased plasma triglycerides
    • 3.) Decreased triglyceride synthesis
Card Set
I am a big fan of grizzly bears.