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Atorvastatin

  1. To what class of drugs does atorvastatin belong?
    HMG-CoA Reductase Inhibitors.
  2. What are the indications associated with atorvastatin?
    • Hypercholesterolemia
    • Mixed dyslipidemia
  3. True or false?

    The active portion of atorvastatin's chemical structure resembles a steroid.
    False.

    The active portion of atorvastatin's chemical structure resembles a fatty acid.
  4. True or false?

    Atorvastatin is metabolized into both an active and inactive form.
    True.
  5. What is atorvastatin's target MOA?
    By competitively inhibiting HMG-CoA reductase, it decreases mevalonate, the precursor to cholesterol. This is the rate limiting step in cholesterol synthesis.
  6. As per atorvastatin's MOA, what happens to cholesterol synthesis in the liver?
    Cholesterol synthesis decreases.
  7. As per atorvastatin's MOA, what happens to the expression of LDL receptors on the liver?
    Expression of LDL receptors on the liver increase, thus increasing the clearance of LDL from the blood.
  8. What pleiotropic effects are associated with atorvastatin?
    The blood becomes less coagulable --> an unexplainable effect of the drug.
  9. True or false?

    Statins have a higher affinity for HMG-CoA reductase than does HMG-CoA.
    True.
  10. What are some adverse effects associated with atorvastatin?
    • Myalgia (acceptable if patient can tolerate)
    • Myopathy, myositis
    • Rhabdomyolysis
    • Abnormal LFTs
    • Constipation (from lack of bile salts)
    • Xanthomas
  11. What effect does estrogen have on HMG-CoA reductase?
    Estrogen may negatively regulate the enzyme, and so pre-menopausal women may have some protection against AVD.
Author
jdonaldson
ID
73752
Card Set
Atorvastatin
Description
As if all of that weren't enough, Spinler keeps wearing red... the color of blood.
Updated

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