-
Cimetidine
- Reversible block of histamine H2 receptors -> decreased H secretion by parietal cells
- Inhibitor of P-450, antiandrogenic effects, crosses BBB and placenta, decreased renal creatinine excretion
-
Omeprazole
PPI - irreversibly inhibits H/K ATPase in stomach parietal cells
-
Bismuth, scralfate
- Bind to ulcer base, provides protection, allos HCO3 secretion to reestablish pH gradient
- Part of triple therapy for H pylori (with metronidazole and amoxicillin or tetracycline)
-
Misoprostol
- PGE1 analog - increases production and secretion of gastric mucous barrier, decreases acid production
- Prevention of NSAID-induced peptic ulcers, maintenance of PDA, inducing labor
-
Pirenzepine, propantheline
- Muscarinic antagonists
- Block M1 receptors on ECL cells (decreased histamine secretion) and M3 receptors on parietal cells (decreased H secretion)
- Can cause tachycardia, dry mouth, difficulty focusing eyes
-
Aluminum hydroxide
Magnesium hydroxide
Calcium carbonate
- Constipation
- Diarrhea
- Hypercalcemia
- All can cause hypokalemia
-
Infliximab
- Monoclonal Ab to TNF
- Used in Crohn's disease, ulcerative colitis, rheumatoid arthritis
- Can reactivate latent TB
-
Sulfasalazine
- Sulfapyridine (antibacterial) + 5-ASA (antiinflammatory)
- Activated by colonic bacteria
- Used for UC, Crohn's disease
- Can cause reversible oligospermia
-
Ondansetron
- 5HT3 antagonist - central acting antiemetic
- Can cause headache, constipation
-
Metoclopramide
- D2 receptor antagonist
- Increased resting tone, contractility, LES tone, motility
- Used in diabetic and post-surgery gastroparesis, N/V from chemo
- Can have parkinsonian effects; contraindicated in SBO
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