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What do Adrenergic drugs do?
influence SNS activity
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What are adrenergic agonists?
Sympathomimetics; augment sympathetic response
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Adrenergic antagonists
sympatholytics; attenuate sympathetic-induced activity
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Mephenteramine
- Wyamine
- Alpha-1 selective agonist
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Methoxamine
- Vasoxyl
- Alpha-1 selective agonist
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Midodrine
- ProAmatine
- Alpha-1 selective agonist
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*Oxymetazoline
MOA?
- Afrin/Visine
- Alpha-1 selective agonist
- decreases nasal congestion and eye reddness
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*Phenylephrine
What does it treat?
- Neo-Synephrine
- Alpha-1 selective agonist
- Treats hypotension and terminates supraventricular tachycardia
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*Pseudoephedrine
Alpha-1 selective agonist
what does it do?
- Drixoral/Sudafed
- Alpha-1 selective agonist
- -Decongestant
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Xylometazoline
- Otrivin
- Alpha-1 selective agonist
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Brimonidine
- Alphagan
- Alpha-2 Selective Agonist
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Clonidine
- Catapres, Duraclon
- Alpha-2 Selective Agonist
- Anti-HTN and analgesic
- antispasticity effects
- Caution: causes hypotension
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Guanabenz
- Wytensin
- Alpha-2 Selective Agonist
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Guanfacine
- Tenex
- Alpha-2 Selective Agonist
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Methyldopa
- Aldomet
- Alpha-2 Selective Agonist
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Tizanadine
- Zanaflex
- Alpha-2 Selective Agonist
- treats spasticity; less likely to cause hypotension
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Dobutamine
- Dobutrex
- Beta-1 selective Agonist
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Dopamine
- Intropin
- Beta-1 selective Agonist
- Stimulates HR and increases PVR (alpha-1 effect)
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Albuterol
- Proventil, Ventolin
- Beta-2-selective bronchodilator (Agonist)
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Ritodrine
What does it inhibit?
- Yutopar
- Beta-2-selective bronchodilator (Agonist)
- Inhibits premature labor-mediates relaxation of uterine muscle
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Name (6) drugs that have mixed alpha and beta agonist activity
- Amphetamines-Dextroamphetamine (dexedrine), Methamphetamine (Desoxyn)
- Ephedrine (generic)
- Epinephrine- Adrenalin, Bronkaid Mist, Primatene Mist
- Metaraminol (Aramine)
- Norepinephrine (Levophed)
- Phenylpropanolamine (Acutrim, Dexatrim, Progagest)
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Doxazosin
- Cardura
- Alpha Antagonist
- relaxes smooth muscle (alpha-1 blocker)
- tx BPH to decrease urinary retention
- Antihypersensitive- decreases BP b/c decreases PVR
- dc's total cholesterol and TG's
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Ergot Alkaloids- Ergotamine
- Ergomar
- Alpha Antagonist
- can be a competitive
- vasoconstricts low tone BV's and vasodialates high tone BV's
- Prevents/ aborts vascular HA- cluster HA and migraines via vasoconstriction
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Ergoloid mesylate
- Gerimal, hydergine
- Alpha Antagonist
- produces vasodialation
- ic's mental acuity, alertness in Alzheimer pt.'s w/ dementia via ic'd cerbral blood flow
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Phenoxybenzamine
- Dibenzyline
- Alpha Antagonist
- Noncompetitive alpha-1 blocker
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Phentolamine
- Regitine
- Competitive alpha antagonist
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Prazosin
- Minipress
- compeititive alpha-1 antagonist
- Vasodialates veins and arteries
- Rx essential HTN
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Name (2) adverse effects of Alpha antagonists
reflex tachycardia and orthostatic hypotension
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Atenolol
- Tenormin
- Beta Antagonist
- Long term Rx of HTN, chronic, stable angina and MI
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Labetalol
- Normodyne, Trandate
- Beta Antagonist
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Metoprolol
- Lopressor, Toprol-XL
- Beta Antagonist
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Propranolol
- Inderal
- Beta Antagonist
- classic non-selective beta blocker
- Rx HTN, angina pectoris, arrhythmias, and prevention of MI
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Adverse effects of Beta Antagonists (5)
- bronchoconstriction
- dc'd cardiac function
- orthostatic hypotension
- depression
- lethargy
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Bretylium
- Bretylol
- inhibits release of norepi form adrenergic nerve terminals
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Name (5) other drugs that inhibit adrenergic neurons
- Bretylium
- Guanadrel
- Guanethidine
- Metyrosine
- Rauwolfia alkaloids
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