To what class of drugs does verapamil belong?
CCBs - Non DHP
Target MOA: true or false?
Verapamil more greatly affects myocardial tissue than nifedipine.
What are the indications associated with verapamil?
Arrhythmia (antiarrhtyhmic agent class IV)
Target MOA: to what type of calcium channel and where does verapamil exert its action?
Blocks L-type calcium channels, specifically in the SA and AV nodes of the heart, reducing Ca++ influx and slowing calcium channel recovery.
How does verapamil affect myocardial contractility, SA node rate and AV node conduction velocity?
Decreased myocardial contractility (negative inotrope).
Slows SA pacemaker rate and AV conduction velocity.
What are some adverse effects associated with verapamil?
Bradycardia / AV block
Constipation (via GI smooth muscle relaxation)
True or false?
Verapamil is a CCB that exerts its action on an extracellular site of calcium channels.
Verapamil, unlike nifedipine, is targeted at an intracellular site on calcium channels.