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alpha interferon
Antiviral; treats hepatitis B & C; goal is to decrease viral load.
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propranolol (Inderal)
Beta blocker; reduces portal venous pressure, reduces esophageal varices bleeding.
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vasopressin (Pitressin)
Antidiuretic hormone; hemostasis and control of bleeding in esophageal varices, constriction of splanchnic arterial bed; central diabetes insipidus due to deficient ADH.
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octreotide (Sandostatin)
Antidiarrheal, hormone; treats esophageal varices, decrease bleeding and pressure; treats severe diarrhea by supressing secretion of serotonin and gastroenterohepatic peptides, increasing F&E absorption from GI tract; treats acromegaly by suppressing growth hormone, insulin, and glucagon.
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lactulose (Cephulac)
Reduces ammonia levels in GI tract; acidification of feces, traps ammonia for elimination in feces.
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lamivudine (Epivir)
Antiviral; in conjunction with alpha interferon, treats hepatitis B.
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ribavirin (Rebetol, Virazole)
Antiviral; in conjunction with alpha interferon, treats hepatitis C.
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neomycin sulfate (Neo-Fradin)
Antibiotic; treats hepatic encephalopathy by decreasing number of ammonia-producing bacteria in GI tract.
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misoprostol (Cytotec)
Prostaglandin, antiulcer agent; prevention of gastric mucosal injury from NSAIDs in high-risk patients, decreases gastric acid secretion, increases production of protective mucus.
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metoclopramide (Reglan)
Antiemetic; prevent chemotherapy-related and postop N/V, blocks dopamine receptors in chemorecepter trigger zone of CNS, stimulates upper GI motility and gastric emptying.
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sucralfate (Carafate)
GI protection, antiulcer agent; duodenal ulcers, coats and protects ulcerated surface.
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Anticholinergics
- Competitively inhibit action of acetylcholine
- Atropine: Bradyarrhythmias
- Ipratropium: Broncospasm and rhinorrhea
- Scopolamine: Nausea and vomiting r/t motion sickness and vertigo
- Propantheline & glycopyrrolate: Decreasing gastric secretory activity, increasing esphageal spincter tone
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Laxatives
- Prevent/treat constipation
- Bisacodyl, sennosides: Stimulants
- Magnesium salts & phosphates: Saline laxative
- Docusate: stool softener
- Polycarbophil & psyllium: Bulk-forming agents
- Lactulose, polyethylene, glycol/electrolyte: osmotic carthartics
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5-aminosalicylates (5-ASA) & sulfasalazine (Azulfidine)
GI antiinflammatory, antirheumatic; inflammatory bowel diseases including ulcerative colitis, Crohn's colitis, proctitis, proctosigmoiditis, locally acting in colon where activity of prostaglandin synthesis inhibition is occurring.
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Antacids
Neutrolizes stomach acids by increasing pH.
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Proton pump inhibitors
Reduce gastric acid production by inhibiting proton pump; omeprazole, esomeprazole.
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H2 blockers (H2 receptor antagonists)
Blocks action of histamine on stomach's parietal cells, decreasing production of stomach acid; cimetidine, ranitidine (Zantac).
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