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Lipitor
1.generic
2.class
3.MOA
4.PC
5.SE
6.F
7.DI,DC
- 1.atorvastatin
- 2.statin
- 3.inhibits HMG-CoA reductase
- 4. given anytime during the day due to long 1/2life
- 5. myopathy, myalgia, rhabdomyolysis, increased LFT
- 6. qd
- 7. contraindicated in active or chronic liver disease
-
Lescol XL
- 1.fluvastatin
- 2.statin
- 3.inhibits HMG-CoA reductase
- 4. given HS bc most cholesterol is produced at night
- 5. myopathy, myalgia, rhabdomyolysis, increased LFT
- 6. hs
- 7. contraindicated in active or chronic liver disease
-
Crestor
- 1.rosuvastatin
- 2.statin
- 3.inhibits HMG-CoA reductase
- 4. given HS bc most cholesterol is produced at night. adjust for pt with renal impairment (CrCL<30ml/min) and liver disease
- 5. myopathy, myalgia, rhabdomyolysis, increased LFT
- 6. hs
- 7. contraindicated in active or chronic liver disease
-
Niaspan
- 1.niacin
- 2.nicotinic acid (niacin)
- 3.decrease VLDL synthesis, thus dicrease LDL and TG; may inhibit apolipoproteinA which increases HDL
- 4. give aspirin 325 or ibuprofen 200mg 30min prior to dose to decrease itch and flush
- 5.flush,hyperglycemia,hyperuricemia(gout)
- 6. hs
- 7. use in caution with resins(bile acids); combo with statin and lopid may increase risk of myopathy; do not is if pt has chronic liver disease or severe gout
-
Tricor
- 1.fenofibrate
- 2.fibric acid
- 3.decrease TG by reduction of apo-b; increase HDL by increasing apo-A1 and 2
- 4.with or w/o food; decrease dose if pt has renal impairment
- 5.dyspepsia,gallstones, myopathy(increased when used with statin)
- 6.qd (48-145mg)
- 7.warfarin,cyclosporine,bile acids decrease fibrate abs; do not use if pt has severe renal or hepatic impairment
-
Lovaza
- 1.omega 3 fatty acids
- 2.omega
- 3.decrease heaptic TG synthesis
- 4.with food;avoid if allergic to fish;assess effectivness at 2months(d/c if TG are not decreased adequatily)
- 5.burp, indigestion, backache, taste sense alteration
- 6.4g qd or 2g bid (DF 1g)
- 7.possible prolong bleeding may occur with anticoagulants
-
Zetia
- 1.ezetimibe
- 2.cholesterol inhibitors
- 3.inhibits cholesterol absorption at small intestine brush border
- 4.with or w/o food, may be taken with statins
- 5.increase liver enzymes, GI distress
- 6. QD (10mg)
- 7.cyclosporine increased zetia; combo with resins may decrease abs; combo with fibric acid may lead to gallbladder disease
- DC:mod to severe heaptic disease
-
Vytorin
- 1.ezetimibe and simvastatin
- 2.cholesterol inhibitor and statin
- 3.inhibit cholesterol abs. at small intestine brush border;inhibit HMG-CoA reductase
- 4. given HS
- 5.increase LFT, myopathy,rhabdomyolysis, GI distress
- 6.HS
- 7.contraindicated in liver or heaptic disease
-
Norvasc
- 1.amlodipine
- 2.CCB,dihydropyridine
- 3.inhibits calcium influx into vascular smooth muscle and myocardium
- 4.report dizzy,hypotension, increased swelling
- 5.edema, flush, HA, gingivial hyperplasia
- 6.QD
- 7.grape juice
-
Caduet
- 1.amlodipine-atorvastatin
- 2.CCB,statin
- 3.inihbit calcium influx and HMG-CoA reducatse
- 4.given daily
- 5.myopathy,rhabdo,flush,HA,edema, increased LFT
- 6.QD
- 7.contraindicated in liver disease
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