1. Pregnancy
    • Trimester
    • PRN or QDaily
    • Small or high dose
    • Risks > benefits
    • Review safer options in same theapeutic class
  2. Lactation
    • PRN or QDaily
    • Low or High dose
    • PK-- "pump and dump"
    • Benefits > Risks
    • Therapeutic alternatives that may be more lactation safe based on "evidence"
  3. Adverse Reactions
    • Nature of reaction (onset, duration, severity)
    • Disease profile (symptom, disease changes)
    • Detailed medication history (start and stop dates)
    • PK (onset, duration, severity)
  4. Drug-allergy interactions
    • True allergy or ADR
    • Mechanism of action or cause of interaction (structural, immune, biological pathways, dose-dependent)
    • Onset, duration, severity
    • Documentation
    • Other therapeutic alternatives
  5. Drug, food, herbal, adverse interactions
    • Severity, documentation
    • onset of interaction
    • disease or lifestyle changes
    • dose-dependent
    • transiet or long-term
    • discontinue unnecessary medications/duplications
    • alternative therapeutic options
  6. Dose/administration/dosage forms
    • dosage form desired (patch, sustain release)
    • Pt alert or oriented (IV, NG, PO)
    • Water, sodium, glucose restrictions
  7. Foreign, orphan, investigational drug id
    • Indication
    • Country or region
    • susepcted indication or perceived use
    • spelling
    • physical characteristics of dosage form, color, markings, size
    • Direct us equalivent available
    • no direct us equivalent available but agent with similar action or indication available
  8. Drug of choice
    • indication
    • goal of therapy: acute vs long term
    • patient profile: allergy, age, gender, height weight
    • disease profile: co-morbidities, organ dysfunction
    • medication profile: received/tried/failed, dosage form, dynamics and kinetic
Card Set
DI key ideas