Musc pharm

  1. Aspirin
    • Irreversibly inhibits COX, decreases synthesis of TXA2 and PGE
    • Decreased platelet aggregation, antipyretic and analgesic, anti-inflammatory (with increasing dose)
    • Can lead to acute renal failure, upper GI bleed, Reye's syndrome in kids with viral infection
  2. NSAIDs
    • Ibuprofen, naproxen, indomethicin, ketorolac
    • Reversibly inhibit COX, block prostaglandin synthesis
    • Antipyretic, analgesis, antiinflammatory
    • Indomethicin used to close PDA
    • Can cause renal damage, GI distress, ulcers
  3. Celecoxib
    • Reversibly inhibits COX2 (inflammation and pain); spares COX1 -> maintain gastric mucosa
    • Rheumatoid and osteoarthritis
    • Increased risk of thrombosis, sulfa allergy
  4. Acetaminophen
    • Reversibly inhibits COX, mostly in CNS
    • Antipyretic and analgesic, not anti-inflammatory
    • Overdose produces hepatic necrosis - glutathione depleted; N-acetylcysteine regenerated glutathione
  5. Etidronate, pamidronate, alendronate, risedronate
    • Bisphosphonates
    • Inhibit osteoclastic activity
    • Used in malignancy-associated hypercalcemia, Paget's disease, PMP osteoporosis
    • Can cause corrosive esophagitis
  6. Colchicine
    • Used for acute gout
    • binds and stabilizes tubulin to inhibit polymerization -> impairs neutrophil chemotaxis and degranulation
    • Indomethicin is less toxic to GI, also used in acute gout
  7. Probenecid
    • Inhibits reabsorption of uric acid in PCT (uricosuric)
    • Used for chronic gout prophylaxis
  8. Allopurinol
    • Inhibits xanthine oxidase
    • Used in chronic gout, in lymphoma and leukemia to prevent tumor lysis-associated urate nephropathy
    • Increases concentrations of azathioprine and 6-MP
    • Do not give salicylates in gout - decreased uric acid clearance
  9. Etanercept
    • Recombinant form of humat TNF receptor that binds TNF
    • EtanerCEPT is a TNF decoy reCEPTor
    • RA, psoriasis, ankylosing spondylitis
  10. Infliximab
    • Anti-TNF Ab
    • Crohn's dz, RA, ankylosing spondylitis
    • Predisposes to reactivation with latent TB
  11. Adalimumab
    • Binds TNF alpha
    • RA, psoriasis, ankylosing spondylitis
  12. P-450 inducers
    • Queen Barb Steals Phen-phen and Refuses Greasy Carbs Chronically
    • Quinidine, Barbituates, St. John's wort, Phenytoin, Rifampin, Griseofulvin, Carbamazepine, Chronic alcohol use
  13. P-450 inhibitors
    • Inhibit yourself from drinking beer from a KEG because it makes you Acutely SICk.
    • Ketoconazole, Erythromycin, Grapefruit juice, Sulfonamides, Isoniazid, Cimetidine, Acute alcohol use
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Musc pharm
Musc Pharm