-
Aspirin
- Irreversibly inhibits COX, decreases synthesis of TXA2 and PGE
- Decreased platelet aggregation, antipyretic and analgesic, anti-inflammatory (with increasing dose)
- Can lead to acute renal failure, upper GI bleed, Reye's syndrome in kids with viral infection
-
NSAIDs
- Ibuprofen, naproxen, indomethicin, ketorolac
- Reversibly inhibit COX, block prostaglandin synthesis
- Antipyretic, analgesis, antiinflammatory
- Indomethicin used to close PDA
- Can cause renal damage, GI distress, ulcers
-
Celecoxib
- Reversibly inhibits COX2 (inflammation and pain); spares COX1 -> maintain gastric mucosa
- Rheumatoid and osteoarthritis
- Increased risk of thrombosis, sulfa allergy
-
Acetaminophen
- Reversibly inhibits COX, mostly in CNS
- Antipyretic and analgesic, not anti-inflammatory
- Overdose produces hepatic necrosis - glutathione depleted; N-acetylcysteine regenerated glutathione
-
Etidronate, pamidronate, alendronate, risedronate
- Bisphosphonates
- Inhibit osteoclastic activity
- Used in malignancy-associated hypercalcemia, Paget's disease, PMP osteoporosis
- Can cause corrosive esophagitis
-
Colchicine
- Used for acute gout
- binds and stabilizes tubulin to inhibit polymerization -> impairs neutrophil chemotaxis and degranulation
- Indomethicin is less toxic to GI, also used in acute gout
-
Probenecid
- Inhibits reabsorption of uric acid in PCT (uricosuric)
- Used for chronic gout prophylaxis
-
Allopurinol
- Inhibits xanthine oxidase
- Used in chronic gout, in lymphoma and leukemia to prevent tumor lysis-associated urate nephropathy
- Increases concentrations of azathioprine and 6-MP
- Do not give salicylates in gout - decreased uric acid clearance
-
Etanercept
- Recombinant form of humat TNF receptor that binds TNF
- EtanerCEPT is a TNF decoy reCEPTor
- RA, psoriasis, ankylosing spondylitis
-
Infliximab
- Anti-TNF Ab
- Crohn's dz, RA, ankylosing spondylitis
- Predisposes to reactivation with latent TB
-
Adalimumab
- Binds TNF alpha
- RA, psoriasis, ankylosing spondylitis
-
P-450 inducers
- Queen Barb Steals Phen-phen and Refuses Greasy Carbs Chronically
- Quinidine, Barbituates, St. John's wort, Phenytoin, Rifampin, Griseofulvin, Carbamazepine, Chronic alcohol use
-
P-450 inhibitors
- Inhibit yourself from drinking beer from a KEG because it makes you Acutely SICk.
- Ketoconazole, Erythromycin, Grapefruit juice, Sulfonamides, Isoniazid, Cimetidine, Acute alcohol use
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