Mouse Blue Book review questions

  1. 1. What is the Subfamily of the laboratory mouse?
  2. 2. Mice have _________(how many?) chromosomes that are differentiated by the size and pattern of transverse bands.
  3. 3. Brother-sister mating system for more than 20 generations with heterozygosity for the mutations forced by (1) backcrossing, (2) intercrossing, (3) crossing and intercrossing, or (4) backcrossing and intercrossing is defined as what term?
    segregating inbred strain
  4. 4. Occurrence of a mutation of interest within a strain is known as:
    coisogenic inbred strains
  5. 5. A mutation or gene of interest transferred by repeated backcrossing of mutation bearing mice for 10 or more generations or a cross-intercross system for the equivalent of 20 or more cycles within an inbred parent strain is known as:
    congenic inbred strains
  6. 6. Nonsibling matings from an F2 of a cross between two inbred strain is known as:
    advanced intercross lines
  7. 7. CBA/J mouse carries the gene for what disorder?
    Retinal degeneration
  8. 8. Mice consume about ________ of feed per day after weaning and maintain this intake throughout life.
    3-5 grams
  9. 9. Adult mice drink ______ of water per day.
    6-7 ml
  10. 10. The mouse responds to cold exposure, for example by _____________.
    nonshivering thermogenesis
  11. 11. The neotatal mouse is ectothermic and does not have well-developed temperature control before ___ days of age.
  12. 12. _________ is always present in mouse urine; __________is always absent from mouse urine.
    taurine, tryptophan
  13. 13. In the mouse, the submaxillary salivary gland secretes what type of saliva?
  14. 15. How many pairs of mammary glands does a normal female mouse possess?
  15. 14.How many molars are in each quadrant of the mouse dental arcade?
  16. 16. During which phase of the estrous cycle does ovulation occur in the mouse ?
  17. 17. The phase of the estrous cycle during which there are no leukocytes present or identified
  18. 19. Which of the following effects is characterized by the suppression of estrus in mice housed in large groups?
    Lee-Boot effect
  19. 20. Which of the following effects is characterized by the pheromones from a strange male mouse, particularly of a different strain, preventing implantation or causing pseudo-pregnancy in recently bred female mice?
    Bruce effect
  20. 21. Which of the following factors does not play a role in signaling the estrus cycle ?
    circadian rhythm
  21. 22. Secretions from what two components make up the vaginal plug?.
    vesicular and coagulating glands
  22. 23. What hormone is required for nursing but not essential for parturition or reproductive behavior?
  23. 24. ________________ are MHC class II restricted and promote B lymphocytes responses essential for humoral immunity.
    CD4 + T cells
  24. 25. This mouse model has a defective transcription factor gene controlling thymic epithelial cell differentiation and is uses in tumor and xenograft studies.
    nude mouse (athymic and hairless)
  25. 26. This mouse has a mutation on c�some 13, which affects pigment granules and lysosomal granules of type II pneumocytes, mast cells, and NK cells.
    beige mouse
  26. 27. This mouse has a defect in Bruton�s tyrosine kinase gene affecting signal transduction in B cells. It has decreased B cell numbers and low IgM
    XID mouse (used as a model for human x-linked agammaglobulinemia)
  27. 28. This mouse is used for tumor and xenograft transplantation because it has no Ig or T cell responses.
    SCID mouse (it has a defective DNA-dependent kinase that recombines gene segments coding for T and B cell receptors)
  28. 29. List the strain of ectromelia virus that has low virulence.
    Hampstead (Moscow and NIH-79 strains have high virulence)
  29. 30. Natural transmission of mouse hepatitis virus (MHV) is facilitated by:
    intermediately resistant mice
  30. 31. Which of the following listed are usually more susceptible to lethal infection of MHV?
    infant mice and aged mice
  31. 32. Ectromelia virus multiply in the cell cytoplasm and produces what two types of inclusion bodies?
    Type A and B
  32. 33. Name the two herpes viruses in which mice are naturally susceptible?
    Mouse cytomegalovirus, Thymic necrosis virus
  33. 34. What type of herpes viruses is mouse cytomegalovirus?
  34. 36. MVM can be differentiated from MPV using virus-specific _____ antigens.
  35. 37. Adenoviruses are enveloped/nonenveloped DNA/RNA viruses that produce _______ inclusions in vitro and in vivo.
    nonenveloped, DNA, intranuclear
  36. 38. In what tissue do the MAdV replicate?
    kidney tissue culture
  37. 39. _______________ used to be a togavirus, now Arterivirus specific to mice that increases the concentration of several serum enzymes
    Lactate Dehydrogenase-Elevating Virus
  38. 40. Name a strain of mice that show a �spectacular� increase in LDH levels (15-20x normal levels) when infected with LDV?
  39. 41. Which common laboratory species is susceptible to LCMV infection.
    Mouse, hamster, guinea pig
  40. 42. Which of the following lesions is characteristically seen with Sendai virus infection ?
    multinucleated syncytia, squamous metaplasia of bronchial epithelium, adenomatoid appearance of terminal bronchioles
  41. 43. Clinical signs of rotavirus infection occur in mice less than ________ weeks old.
  42. 44. One of the helpful features for differentiating EDIM virus infection in neonatal mice from that of other enteric infections is ______________.
    b. the presence of milk in the stomach
  43. 45. Which of the following is diagnostic for detecting MHV?
    The use of immunodeficient mice as sentinels, Neutralization tests, Detection of synctia augmented by immunohistochemistry
  44. 46. Flaccid posterior paralysis and possible weakness in fore limbs in mice that are otherwise alert is a characteristic sign of what disease
  45. 47. _____ are significant reservoirs of M. pulmonis infection for mice.
  46. 48.. Besides Mycoplasma neurolyticum, what is another differential for rolling in mice?
  47. 49. What aspect of the GI vilus does Helicobacter colonize in mice?
  48. 50. ________ ________ , a novel urease negative helicobacter, causes inflammatory bowel disease in both IL10-/- and SCID mice.
    Helicobacter typhlonius
  49. 51. Which of the following Salmonella spp. is most frequently isolated from mice ?
    Salmonella enteritidis, Salmonella typhimurium
  50. 52. Which of the following factors has an attenuating effect on the severity of salmonella infection in mice ?
    iron deficiency
  51. 53. Hyperplastic typhlocolitis resembling transmissible murine colonic hyperplasia has been reported in ______________ mice with a non-fermenting E. coli.
    SCID mice
  52. 54. __________ is an elongated, pear-shaped, bilaterally symmetrical flagellated protozoan that commonly inhabits the duodenum, usually in the crypts of Lieberkuhn.
    Spironucleus muris
  53. 55. Where could Entamoeba muris be found in mice?
    Cecum, colon
  54. 56. Cryptosporidium parvum inhabits what area of the GI tract?
    small intestines
  55. 57. What coccidia may demonstrate gray spots on the kidneys in heavy infections in mice?
    Klosiella muris
  56. 58. Transmission of spironucleosis can occur between mice and what other rodent?
  57. 59. The life cycle of Syphacia obvelata is direct and completed in ________days.
  58. 60. The life cycle of Myobia musculi is _____ days.
  59. 61. A Reye�s-like syndrome has been reported in _____________ mice.
  60. 62.: A deficiency of which of the following vitamins is best characterized by signs of poor growth, poor reproduction and lactation, and a variety of neurological abnormalities?
    Vitamin B complex
  61. 63: A deficiency of which of the following vitamins is best characterized by signs of decreases in red and white blood cell counts and the disappearance of megakaryocytes and nucleated cells form the spleen?
    Folic acid
  62. 64: A deficiency of which of the following vitamins is best characterized by signs of fatty liver, nodular hepatic hyperplasia, myocardial lesions, decreased conception and decreased viability of litters?
  63. 65. Which of the following mouse strains serve as a model for retinitis pigmentosa ?
  64. 66. Symmetrical mineral deposits are not found in which areas of the brain in aged mice ?
  65. 67. Which of the following conditions should not be considered a differential for urinary tract obstruction in the mouse ?
    polycystic kidney disease
  66. 68. Which of the following is the Vandenbergh effect?
    Accelerated onset of puberty in female when exposed to male pheromone
  67. 69. Which of the following is a conplastic strain?
  68. 70. What is the length of the estrus cycle in the mouse?
    4-5 days
  69. 71. A strain is completely inbred after how many matings?
    40 generations of brother sister mating
  70. 72. The piebald mouse is a model of what disease in humans?
    Hirschsprung disease
  71. 73. The gene affected in the piebald mouse is:
  72. 74. Which chromosome is the gene Tyr found on?
  73. 75. Carbon tetrachloride causes what kind of toxicity?
  74. 77. Which of the following mice have hypocallosity?
  75. 78. On necropsy you see white spots on the liver and a mosaic spleen. What is the cause?
  76. 79. Which of the causes of acariasis of mice is in the suborder Astigmata?
    Mycoptes musculinus
  77. 81. This mouse lacks both B and T cells
    SCID and Rag-2
  78. 82. The motheaten mutant has a recessive mutation on which c�some?
  79. 83. These mutants have a very short lifespan and usually die of pneumonia
    Motheaten mouse
  80. 84. What is the most frequently used mammal for Bone Marrow Transplantation (BMT) studies?
  81. 85. In the article �Sperm Freezing and In Vitro Fertilization in 3 Substrains of B6 Mice�, which strain gave the highest fertilization rate?
  82. 86. In the article �Surgical Oocyte Retrieval (SOR)� In what region of the oviduct was the incision made?
  83. 87. Intracardiac injection of human tumor cells into what type of mouse is an established model of bone metastasis?
    nude mouse
  84. 89. Which two drugs have been proven to be safer and more effective in mice for the treatment of mites
    Fipronil and selamectin
  85. 88. In the procedure in the preceding question, what part of the heart are the tumor cells usually injected into?
    Right ventricle
  86. 90. Which is correct concerning chloroform toxicity in mice?
    Males are more susceptible than females
  87. 91. An investigator wants to purchase some B6-mtCAS mice. What kind of mouse is this?
  88. 92. What is the gene for a mouse being pigmented?
  89. 93. What effect does MHV have on natural killer cell activity?
    Increases it
  90. 94. Susceptibility to psuedomoniasis in mice is enhanced by what?
  91. 95. What mouse strain is most sensitive to MPTP?
  92. 96. What strain of mouse, not considered immunodeficient, is NK cell deficient?
  93. 97. What are the two principal components of the secretions from the Harderian gland?
    Lipid and Porphyrin
  94. 98. What type of mice are typically affected by Scaly Skin Disease?
    Hairless mice (not strictly immunodeficient)
  95. 99. What does LLC stand for (LLC is a mutant mouse)
    Low Leukocyte Count
  96. 100. What does SAM stand for (SAM is another mutant mouse)
    Senescence-Accelerated Mouse
Card Set
Mouse Blue Book review questions
Chapter 3 questions