Mouse Blue Book review questions

1. What is the Subfamily of the laboratory mouse?

2. Mice have _________(how many?) chromosomes that are differentiated by the size and pattern of transverse bands.

3. Brother-sister mating system for more than 20 generations with heterozygosity for the mutations forced by (1) backcrossing, (2) intercrossing, (3) crossing and intercrossing, or (4) backcrossing and intercrossing is defined as what term?

4. Occurrence of a mutation of interest within a strain is known as:

5. A mutation or gene of interest transferred by repeated backcrossing of mutation bearing mice for 10 or more generations or a cross-intercross system for the equivalent of 20 or more cycles within an inbred parent strain is known as:

6. Nonsibling matings from an F2 of a cross between two inbred strain is known as:

7. CBA/J mouse carries the gene for what disorder?

8. Mice consume about ________ of feed per day after weaning and maintain this intake throughout life.

9. Adult mice drink ______ of water per day.

10. The mouse responds to cold exposure, for example by _____________.

11. The neotatal mouse is ectothermic and does not have well-developed temperature control before ___ days of age.

12. _________ is always present in mouse urine; __________is always absent from mouse urine.

13. In the mouse, the submaxillary salivary gland secretes what type of saliva?

15. How many pairs of mammary glands does a normal female mouse possess?

14.How many molars are in each quadrant of the mouse dental arcade?

16. During which phase of the estrous cycle does ovulation occur in the mouse ?

17. The phase of the estrous cycle during which there are no leukocytes present or identified

19. Which of the following effects is characterized by the suppression of estrus in mice housed in large groups?

20. Which of the following effects is characterized by the pheromones from a strange male mouse, particularly of a different strain, preventing implantation or causing pseudo-pregnancy in recently bred female mice?

21. Which of the following factors does not play a role in signaling the estrus cycle ?

22. Secretions from what two components make up the vaginal plug?.

23. What hormone is required for nursing but not essential for parturition or reproductive behavior?

24. ________________ are MHC class II restricted and promote B lymphocytes responses essential for humoral immunity.

25. This mouse model has a defective transcription factor gene controlling thymic epithelial cell differentiation and is uses in tumor and xenograft studies.

26. This mouse has a mutation on c�some 13, which affects pigment granules and lysosomal granules of type II pneumocytes, mast cells, and NK cells.

27. This mouse has a defect in Bruton�s tyrosine kinase gene affecting signal transduction in B cells. It has decreased B cell numbers and low IgM

28. This mouse is used for tumor and xenograft transplantation because it has no Ig or T cell responses.

29. List the strain of ectromelia virus that has low virulence.

30. Natural transmission of mouse hepatitis virus (MHV) is facilitated by:

31. Which of the following listed are usually more susceptible to lethal infection of MHV?

32. Ectromelia virus multiply in the cell cytoplasm and produces what two types of inclusion bodies?

33. Name the two herpes viruses in which mice are naturally susceptible?

34. What type of herpes viruses is mouse cytomegalovirus?

36. MVM can be differentiated from MPV using virus-specific _____ antigens.

37. Adenoviruses are enveloped/nonenveloped DNA/RNA viruses that produce _______ inclusions in vitro and in vivo.

38. In what tissue do the MAdV replicate?

39. _______________ used to be a togavirus, now Arterivirus specific to mice that increases the concentration of several serum enzymes

40. Name a strain of mice that show a �spectacular� increase in LDH levels (15-20x normal levels) when infected with LDV?

41. Which common laboratory species is susceptible to LCMV infection.

42. Which of the following lesions is characteristically seen with Sendai virus infection ?

43. Clinical signs of rotavirus infection occur in mice less than ________ weeks old.

44. One of the helpful features for differentiating EDIM virus infection in neonatal mice from that of other enteric infections is ______________.

45. Which of the following is diagnostic for detecting MHV?

46. Flaccid posterior paralysis and possible weakness in fore limbs in mice that are otherwise alert is a characteristic sign of what disease

47. _____ are significant reservoirs of M. pulmonis infection for mice.

48.. Besides Mycoplasma neurolyticum, what is another differential for rolling in mice?

49. What aspect of the GI vilus does Helicobacter colonize in mice?

50. ________ ________ , a novel urease negative helicobacter, causes inflammatory bowel disease in both IL10-/- and SCID mice.

51. Which of the following Salmonella spp. is most frequently isolated from mice ?

52. Which of the following factors has an attenuating effect on the severity of salmonella infection in mice ?

53. Hyperplastic typhlocolitis resembling transmissible murine colonic hyperplasia has been reported in ______________ mice with a non-fermenting E. coli.

54. __________ is an elongated, pear-shaped, bilaterally symmetrical flagellated protozoan that commonly inhabits the duodenum, usually in the crypts of Lieberkuhn.

55. Where could Entamoeba muris be found in mice?

56. Cryptosporidium parvum inhabits what area of the GI tract?

57. What coccidia may demonstrate gray spots on the kidneys in heavy infections in mice?

58. Transmission of spironucleosis can occur between mice and what other rodent?

59. The life cycle of Syphacia obvelata is direct and completed in ________days.

60. The life cycle of Myobia musculi is _____ days.

61. A Reye�s-like syndrome has been reported in _____________ mice.

62.: A deficiency of which of the following vitamins is best characterized by signs of poor growth, poor reproduction and lactation, and a variety of neurological abnormalities?

63: A deficiency of which of the following vitamins is best characterized by signs of decreases in red and white blood cell counts and the disappearance of megakaryocytes and nucleated cells form the spleen?

64: A deficiency of which of the following vitamins is best characterized by signs of fatty liver, nodular hepatic hyperplasia, myocardial lesions, decreased conception and decreased viability of litters?

65. Which of the following mouse strains serve as a model for retinitis pigmentosa ?

66. Symmetrical mineral deposits are not found in which areas of the brain in aged mice ?

67. Which of the following conditions should not be considered a differential for urinary tract obstruction in the mouse ?

68. Which of the following is the Vandenbergh effect?

69. Which of the following is a conplastic strain?

70. What is the length of the estrus cycle in the mouse?

71. A strain is completely inbred after how many matings?

72. The piebald mouse is a model of what disease in humans?

73. The gene affected in the piebald mouse is:

74. Which chromosome is the gene Tyr found on?

75. Carbon tetrachloride causes what kind of toxicity?

77. Which of the following mice have hypocallosity?

78. On necropsy you see white spots on the liver and a mosaic spleen. What is the cause?

79. Which of the causes of acariasis of mice is in the suborder Astigmata?

81. This mouse lacks both B and T cells

82. The motheaten mutant has a recessive mutation on which c�some?

83. These mutants have a very short lifespan and usually die of pneumonia

84. What is the most frequently used mammal for Bone Marrow Transplantation (BMT) studies?

85. In the article �Sperm Freezing and In Vitro Fertilization in 3 Substrains of B6 Mice�, which strain gave the highest fertilization rate?

86. In the article �Surgical Oocyte Retrieval (SOR)� In what region of the oviduct was the incision made?

87. Intracardiac injection of human tumor cells into what type of mouse is an established model of bone metastasis?

89. Which two drugs have been proven to be safer and more effective in mice for the treatment of mites

88. In the procedure in the preceding question, what part of the heart are the tumor cells usually injected into?

90. Which is correct concerning chloroform toxicity in mice?

91. An investigator wants to purchase some B6-mtCAS mice. What kind of mouse is this?

92. What is the gene for a mouse being pigmented?

93. What effect does MHV have on natural killer cell activity?

94. Susceptibility to psuedomoniasis in mice is enhanced by what?

95. What mouse strain is most sensitive to MPTP?

96. What strain of mouse, not considered immunodeficient, is NK cell deficient?

97. What are the two principal components of the secretions from the Harderian gland?

98. What type of mice are typically affected by Scaly Skin Disease?

99. What does LLC stand for (LLC is a mutant mouse)

100. What does SAM stand for (SAM is another mutant mouse)