-
Anaphylaxis (bee sting, food/drug allergies)
Type I
-
Allergic and atopic disorders (rhinitis, hay fever, eczema, hives, asthma)
Type I
-
-
Pernicious anemia
Type II
-
Idiopathic thrombocytopenic purpura
Type II
-
Erythroblastosis fetalis
Type II
-
Acute hemolytic transfusion reactions
Type II
-
-
Goodpasture's syndrome
Type II
-
Bullous pemphigoid
Type II
-
Pemphigus vulgaris
Type II
-
-
Myasthenia Gravis
Type II
-
-
-
Polyarteritis nodosa
Type III
-
-
-
-
Hypersensitivity pneumonitis
Type III
-
-
-
-
-
-
-
Contact dermatitis
Type IV
-
Recurrent bacterial infections due to opsonization defect
Low B cells and immunoglobulins
- Bruton's agammaglobulinemia
- BTK defect blocks B cell differentiation
-
Severe pyogenic infections
Defective CD40 ligand on helper T cells
- Hyper-IgM syndrome
- Inability to class switch
-
Chronic giardiasis
Sinus and lung infections
Anaphylaxis on exposure to blood products
- IgA deficiency (most common Ig deficiency)
- Defect in isotype switching
-
Defect in B cell maturation
Low plasma cells and immunoglobulin (normal number of B cells)
increased risk of autoimmune disease, lymphoma, sinopulmonary infections
Common variable immunodeficiency (CVID)
-
Tetany, recurrent viral/fungal infections, congenital heart and great vessel defects
- DiGeorge syndrome
- 22q11 deletion - failure of 3rd and 4th pharyngeal pouches to develop (thymus and parathyroids)
- Low ears, HTN, shortened philtrum
-
Disseminated mycobacterial infections
- IL-12 receptor deficiency
- Decreased Th1 response, decreased IFN gamma
-
Coarse facies, cold staph abscesses, retained primary teeth, increased IgE, eczema
- Hype-IgE/Job's syndrome
- Lack of IFN gamma - neutrophils don't respond to chemotactic stimuli
-
Candida infections of skin and mucous membranes
- Chronic mucocutaneous candidiasis
- T cell dysfunction
-
Recurrent viral, bacterial, fungal and protozoal infections
- Severe combine immunodeficiency
- Defective IL-2 receptor, adenosine deaminase deficiency, failure to synthesize MHC II antigens
- B and T cell deficiency; treat with BMT
-
Thrombocytopenic purpura, infections, eczema
- Wiskott-Aldrich syndrome
- X-linked deletion of B and T cells
- Low IgM, high IgE and IgA
-
Recurrent bacterial infections without pus formation, delayed separation of umbilicus
- Leukocyte adhesion deficiency
- Defect in LFA-1
- Neutrophilia
-
Pyogenic infections by staph and strep, partial albinism, peripheral neuropathy
- Chediak-Higashi syndrome
- AR defect in microtubular function with decreased phagocytosis
-
Lack of NADPH oxidase
- Crhonic granulomatous disease
- Increased susceptibility to catalase positive organisms (S. aureus, Aspergillus)
- Negative Nitroblue tetrazolium reduction test
-
Ab-mediated rejection due to presence of preformed antidonor Abs in recipient
Within minutes after transplant
Hyperacute rejection
-
Cell mediated rejection due to cytotoxic T cells reacting against foreign MHC
Occurs weeks after transplant
Reversible
Acute rejection
-
CT cell and Ab-mediated vascular damage (fibrosis) monts to years after transplant
Chronic rejection
-
Severe organ dysfunction, maculopapular rash, jaundice, HSM, diarrhea
GVHD
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