____ regulate salt and water balance by controlling kideny excretions of potassium and sodium retention.
1. glucocorticoids
2. minerocorticoids
2. minerocorticoids
Glucocorticoids regulate ______ metabilism.
carbohydrate
And adrenal medulla secretes ______ and ________.
epinephrine and norepinephrine
The hormonal secretions of the pituitary gland are controlled by the?
hypothalamus
Oxytocin is secreted by the _____ pituitary gland and causes ______________.
posterior
contraction of smooth muscle
The ________ is a butterfly-shaped gland consisting of two lobes.
thyroid
The ______ glands are the glands responsible for controlling levels of blood calcium and phosphate.
parathyroid
_______ is a common endocrine disorder when beta cells in the islets of Langerhans fail to secrete insulin.
Diabetes mellitus
Hyperfunction of the pituitary gland (nontumorous) is most often the cause of __________.
cushing's syndrome
Endocrine glands possess?
no ducts
What are the endocrine glands?
pituitary
thyroid
parathyroid
adrenal
pancreas (both endocrine and exocrine)
sex glands
thymus
Adrenal gland secretions. Cotex? Medulla?
Cortex- steriod hormones, sex hormones
Medulla- epinephrine and norepinephrine
Path? Excess production of glucocorticoid hormones from the adrenal cortex (raises blood sugar), lipid levels increase, obesity of trunk, buffalo hump, moon shaped face?
cushing's syndrome (hyperadrenalism)
Hyperadrenalism is also called?
cushings syndrome
Hypoadrenalism is also called?
addisons disease
Path? Adrenal insufficiency caused by atrophy of adrenal cortex, fails to secrete aldosterone, pt unable to retain salt and water, hyperpigmentation over joints?
addisons disease (hypoadrenalism)
Adrenal carcinomas metastasis to?
lymp nodes and liver
______ is the 2nd most common malignancy in children.
Neuroblastoma (of adrenal medullary origin)
It is important to differentiate _________ (adrenal origin) from _______ tumor which is a urinary system disease.
Neuroblastoma
Wilm's
With neuroblastoms vs Wilm's tumor, which disease is more likely to show calcifications?
neuroblastoma
What is the hypophysis also called?
pituitary gland
The anterior portion of the pituitary gland communicated with the ______ of the brain and secretes _____ and _____.
hypothalamus
growth hormone and sex hormones
The anterior portion of the pituitary gland ____ hormones whereas the posterior portion ________ hormones.
secretes
stores for further use
_____ portion of the pituitary gland receives hormones from the hypothalamus which travels over nerve fibers and stores hormones for further use.
posterior (called neurohypophysis)
ADH (antidiretic hormone) is stored in the _____ lobe of the pituitary and increases the rate of _____ reabsorption in the renal tubules.
posterior
water/electrolyter
Oxytocin is stored in the _____ lobe of the pituitary and causes smooth muscle _______, especially in the uterus.
posterior
contraction
Hyperpituitarism produces ____ and _____.
gigantism
acromegally
Gigantism is excess growth hormone ____ puberty.
Acromegally is excessive growth hormone ____ puberty.
before
after
Diabetes ______ is caused by the absence of ADH.
insipidis
Polyuria and polydipsia are symptoms of?
diabetes insipidis
polyuria= large amounts of diluted urine
polydipsia= very thirsty all the time
Creatinism is caused by _______ of thyroid hormone (from birth) which can lead to a dwarf with stalky features.
insufficient production
Myxedema is adult onset __________.
hypothyroidism
_____ disease is the most common type of hyperthyroidism which usually effects women 3-50yrs old.
Graves
What is exophthalmos, and what disease is it linked to?
outward protrusion of the eyes,
graves disease
What is a goiter?
enlargment of thyroid gland
Most common type of thyroid cancer?
papillary carcinoma
Parathormone is responsible for regulating blood levels of ______ and _______ and are secreted by the ______ glands.
calcium and phosphate
parathyroid glands
Note: Increased PTH secretion causes osteoclasts to remove bone. PTH secretion is controlled by calcium levels in the blood.
Endocrine function of the pancreas is to control glucose levels by secreting _______ and ________.
Insulin and glucagon
Insulin _____ blood sugar.
lowers. Is secreted by beta cells in the islets of langerhans
Glucagon _____ blood glucose.
raises. Is secreted by apha cells in the islets of Langerhans
Hyperglycemia (Diabetes Mellitus): two types?
insulin dependant (more serious), noninsulin dependant (usually later in life)
Renal disease is the leading cause of death with _________.
diabetes mellitus
Path? Hyperglycemic, too much glucagone, skin and tongue dry, fruity asitone breath, pt drowsy and lethargic before onset, can lead to coma and death, requires a large dose of insulin.
diabetic coma
Path? Hypoglycemic, too much insulin, shallow breathing, pt sweats a lot, normal breath odor.
Insulin shock
The modality of choice to determine the function of the thyroid for both palpable and nonpalpable nodules is?
Nuc Med
What are the three types of thyroid carcinomas?
papillary (most common)
follicular
medullary
vasopressin is also known as?
ADH
What is the master gland that is controlled by the hypothalamus?
pituitary
A lack of insulin prevents glucose from entering cells?
diabetes mellitus
Excessive production of thyroxine?
hyperthyroidism (thyroxine- iodine)
Kidney's inablility to conserve water, resulting in low blood levels of ADH.
Diabetes insipidis
_____ predominantly affects females symptomatically as nervousness, emotional liability, and inability to sleep.
Graves disease
The gland that controls the level of secretion of gonadal and thyroid hormones and production of GH is the _____ gland.
pituitary
An enlargemtn of the thyroid gland that is not inflammatory or neoplastic is?
a goiter
The thyroid carcinoma that closely mimics normal thyroid tissue is the _____ type.
follicular
Common manifestations of diabetes ______ are polyuria, polydipsia, and glycosuria.
mellitus
The hormones regulating carbohydrate metabolism are
A. glucocorticoids
The most common cause of hypoadrenalism is?
steriod administration
Diabetes mellitus is a result of the ____ failing to produce _____.
pancreas
insulin
The adrenal cortex secretes?
sex hormones and steroids
The adrenal medulla secretes?
Epi and norepi
Hyperadrenalism (_____) syndrome is an excess production of ___________.
cushing's
glucocorticoid hormones
Hypoadrenalism (_______) disease, adrenals fail to secrete ________.
Addison's
aldosterone
Diabetes insipidus is caused by the absence of _______.
ADH, antidiretic hormone
Creatinism is caused by insufficient production of _______ hormone.
thyroid
Myxedema is adult onset __________.
hypothyroidism
Graves disease is caused by an excess production of ______ hormone.
thyroid
A simple goiter is caused by the thyroid gland's inability to produce ________ hormone.
thyroxine (lack of iodine)
Toxic goiter is caused by the tyroid's overproduction of?
thyroid hormone (accumulation of iodine causes enlargement)
Parathyroid glands secrete _________ which is responsible for regulating blood levels of calcium and phosphate.
parathormone (PTH)- closed loop feed back
Glucagone _____ blood sugar and may also be given during _____.