Pharm Midterm I, IV

  1. Which opioid was developed for drug addicts, has longer duration of action, and popular in equine?
  2. Which opioid is 10 times for potent that morphine and is not licensed in UK or Australia?
  3. Which opioid has an onset of 2-3 mins after IV, has a duration of action around 20 mins, is given by bolus, and produces bradycardia and respiratory depression?
  4. Which opioid is a reasonable analgesic for visceral or soft tissue pain, especially in cats, but has ceiling effect?
  5. Which opioid has an onset of action relatively slow after IV (20 mins), is a poor analgesic agent but good sedative and anti-tussive?
  6. What is the most commonly used opioid antagonist?
  7. How do NSAIDs work and what effects do they have?
    • Inhibit synthesis of eicosanoids from arachidonic acid
    • Peripheral - anti-inflammatory and anti-hyperalgesic
    • Central - anti-central sensitization
  8. No other NSAID licensed for animal use is highly selective for COX-2 except for ________?
    • Firecoxib
    • Deracoxib
  9. What are some side effects of NSAID treatment?
    • Gastro-intestinal ulcers
    • Nephrotoxicity
    • Depressed platelet aggregation
    • Plasma protein binding
  10. What are some contraindication for NSAID use?
    • Renal or hepatic disease
    • Dehydration, hypovolemia
    • gastric ulceration
    • renal dysfunction
  11. Which animal should you give NSAIDs to carefully dosed, and for longer intervals than dogs?
    Cats, deficient in glucuronidation enzymes
  12. What NSAID provides analgesia through antagonism of the N-methyl-D-aspartate (NMDA) glutamate receptor and is recommended for burn wounds and phantom limb pains?
  13. Is the effective dose of alpha2-agonist significantly lower or higher than typically used for sedative purposes?
  14. What alpha2 agonist is considered an "atypical opioid", has agonist properties at all opioid receptors, stimulates the release of serotonin, and is useful in older dogs with chronic pain?
  15. Which alpha2 agonists mode of analgesic action is attributed to action on voltage-gated N-type calcium channels and is used for treating chronic pain syndromes, particularly neuropathic pain?
  16. Which alpha2 agonist has analgesic effects related to its NMDA antagonist effects (similar to ketamine) and was originally developed as an antiviral drug for use in humans?
Card Set
Pharm Midterm I, IV
Pharm Midterm I, IV