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Cite differentiating characteristics:
- Lymph
- Trabecula which seperate follicle chambers around the afferent vessel perimeter
- Medulary cords and sinuses in the center and toward the efferent (1 or 2) vessels
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Name 2 functions of this organ
- Spleen - There are no trabeculae in the spleen
- "White Pulp" contains lumphocytes responsible for the immun functions of the spleen.
- Macrophages in the "Red Pulp" remove worn out RBCs, debris, bacteria, viruses, and toxins from blood flowing through.
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Name 2 functions of this organ
- Lymph node: 1) filtering through T & B-cells,and 2) filtering through macrophages.
- Follicles and within them a globular mass called a germinal center which contains rapidly dividing B-cells. The remainder of the follicle area is T-cells.
- Trabecula
- Subcapsular sinus
- Capsule
- Medullary cords - containing macrophages
- Medullary sinuses
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All lymphoid tissue (except these?) contains T & B-cells:
Thymus & Bone Marrow
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- Spleen
- Shown: Capsule with Red Pulp & White Pulp
- Lymphocytes are suspended in White Pulp and are responsible for the immune functions of the spleen.
- Macrophages of the red Pulp remove worn-out RBC, debris, bacteria, viruses and toxins from the blood.
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- Cervical nodes
- Axillary nodes
- Thoracic duct
- Spleen
- Cisterna Chyli
- Inguinal ducts
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Secondary Lymphoid Areas?
- STAPL
- Spleen
- Tonsils
- Appendix
- Peyer’s patches
- Lymph Nodes
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What is the Cisterna chili?
Enlarged terminus of the thoracic duct which drains lymph from digestive viscera.
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How does the composition of lymph in the Cisterna Chyli differ from that in the general lymphatic stream?
It includes “chyli” or fatty acids from the intestines.
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(Q16) Know the structure of antibodies and the basics about 5 classes of them.
- 2 heavy & constant polypeptide chains (the base) bound with 2 disulfide bonds to 2 sets of chains forming a Y, with constant sections close to the bonds and variable sections further out. In addition the outer chains are “light”, while the inner chains are “heavy”.
- I am MAD at GE for not hiring me.
- IgM First released during immunization. Elevated levels indicate INFECTION.
- IgA Fights local infection; major antibody present in mucus, saliva, and tears.
- IgD Don’t know…
- IgG Found in Blood, Lymph, Cerebrospinal fluid (CSF): Toxin neutralization; Opsonization; Compliment, Immobilization of bacteria.
- IgE Allergic reactions and parasitic worm infections
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Primary Lymphoid organs?
- (Areas where T & B-cells are created/matured.)
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