BioChem Block 2

1. Which of the following types of mutations can
lead to a cancer cell?

1. Inhibition of a tumor suppressor gene








2. Inhibition of a proto-oncogene








3. Activation of a tumor suppressor gene








4. Activation of a proto-oncogene








5. None of the above

2. Which of the following are properties of
cancer cells?

1. They are contact inhibited.




2. They readily enter apoptosis.




3. They generally have mutations in repair mechanisms.




4. They have inhibited their telomerase activities.




5. They all have activated p53 genes.

3. How many different mutations are required to
convert a normal cell into a cancer cell?

1. 0






2. 1






3. 2






4. 3






5. Many

4. How many mutant alleles are required at a
proto-oncogene locus for it to cause growth in an unregulated manner?

1. 0






2. 1






3. 2






4. 3






5. Many

5. How many mutant alleles are required at a
tumor suppressor gene locus for it to cause growth in an unregulated manner?

1. 0






2. 1






3. 2






4. 3






5. Many

6. Associate the folowing:

1. Stimulation of GTP’ase activity






2. Inactive form of a G protein






3. Active form of a G protein






4. p53






5. Hypophosphorylated Rb1






6. Hyperphosphorylated Rb1






7. Activation of MYC

___
E2F

___
Beta catenin

___
GTP

___
GDP

___
apoptosis

___
Ras GAP