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Name the five WBC
- 1) Neutrophils
- 2) Lymphocytes
- 3) Monocytes
- 4) Eiosinophils
- 5) Basophils
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What are the two lineages of Hematopoietic stem cells (HSC's)?
- Myeloid: Macrophages, Granulocytes, RBC, platelets
- Lymphoid: T-cells, B-cells, NK cells
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What are three important cytokines?
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What does IL-3 and IL-7 form?
Lymphoid stem cells
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What does IL-3 + GM-CSF form?
Myeloid line
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What is the difference b/t inducible and constituitive hematopoiesis?
- Inducible: ramp up production due to injury
- Constituitive: Constant production
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What CD is crucial for bone marrow transplants?
CD 34+
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How does antigen presentation work?
- -Phagocytose protein
- -Break down protein and expose antigen on surface of cell
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What is necessary for activation of T-cells?
Antigen presentation (APCs)
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What molecules display antigens on cells?
MHCs
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What four cells utilize APC?
- Monocyte
- Macrophage
- B-lymphocyte
- dendritic cell
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What are two common dendritic cells and where are they found?
- 1) Langerhan: Epidermis
- 3) Interstitial: Organs/tissues
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What are the three granulocytes?
- Neutrophils
- Eiosinophils
- Basophils
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What does left shift mean?
When there are immature Neutrophils due to chronic infection or toxicity
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What is Neutropenia?
<1000 cells (normal is 1800-7700)
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What is Neutrophilia?
>8000 cells (normal 1800-7700)
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What is Eiosinophilia?
>600 cells
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What two cells can stimulate Eiosinophils?
Basophils and Mast Cells
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What are the three destructive enzymes of Eiosinophils?
MBC, ECP, EPO
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What is the difference b/t an effector and a memory cell?
- Effector: used now
- Memory: used later when needed
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What is the main diff b/t T-cell and NK cell?
- T-cell: activated by cells with MHC
- NK cell: activated by cells w/o MHCI
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% monocytes in blood
4-10%
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% eiosinophils that are leukocytes
2-5%
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% basophils that are leukocytes
.5-1%
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What granulocytes are activate by complement factor C3a?
Basophils and Mast cells
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% lymphocytes that are leukocytes
20% - 30%
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% Lymphocytes that are B
5-15%
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% lymphocytes that are T
80%
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What cell is a major target of HIV and why?
TH because of the high immunity it provides through its CD4 marker
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