structure-functure relationship of
relationship (low solubility) 0.42
results in rapid uptake & elimination
partition coefficient of DESFLURANE
solubility in fat (brain)
high solubility = high potency
MAC AWAKE for Desflurane
2.5 (35% of MAC)
MAC BAR for desflurane
1.3 MAC (in 60% N2O)
work so fast?
low solubility in blood & tissue = rapid uptake
FA reaches FI more rapidly with the
agents (WASH IN)
P450 2E1 oxidation
: 2 fluoride ions ; trifluoroacetic acid; CO2 & H2O
WASHOUT most rapid
percutaneous loss is small
VIsceral losses larger than cutaneous
cerebral elimination rapid
How is coronary artery blood flow with
elevation of CVP
CO unchanged/slightly depressed
HR increased with rapid titration
What MAC of desflurane is ICP increased?
1.1 MAC = increased ICP by 7mmHg
What MAC of desflurnane is learning function lost?
How does Desflurane affect SSEP?
decreases SSEP in high concentrations
How does desflurane affect EEG?
low voltage & increased electrical silent @ higher concentrations
iso electric EEG @ 1.5 to 2 MAC
How is CBF affected by Desflurane?
high cerebral vasodilation & low resistance
does NOT alter autoregulation at 1 MAC
abolishment of autoregulation at 1.5 MAC
How is hepatic system affected with Desflurane?
safest of all volatile agents for liver
Advantages of Desflurane?
least soluble = rapid recovery
most myocardial protection against hypoxic results
not degraded by normal CO2 absorbents
pungent (irritation at MAC >1)
transient CV stimulation
dessicated absorbents can degrade into CO
can cause post op agitation in PEDS (
How can u decrease the irritant properties of desflurane?
premedicate with opiods & benzos
NO induction in PEDS (contraindicated)
Which NMBA is potentiated the most?