Nystatin is an _________-_________ drug that increases permeability, which _____ out cellular ______, and leads to cell ____
ergosterol-binding
leaks
components
death
what is used only for superficial candidal infections?
Nystatin
Nystatin is only used for the tx (superficially) of the ____, ____, and ______ mucosa with topical formulations
skin
oral
vaginal
what is added to cream (for dentures), rinses, or lozenges to make them taste better? (Nystatin)
SUGAR! yum!!!
how long must Nystatin contact fungal organism to take effect?
5-7 minutes in the mouth
What is the first choice of drug for primary tx of Candidia Albicans?
Nystatin
what is the formulation of choice of Nystatin in a dental office? _______ ________
oral pastilles (=lozenges, troche "you can hold it "still" in your mouth if its a lozenge or troche")
______ is recommended to prevent caries in conjunction with Nystatin
Fl2
t/f Candida albicans is a normal inhabitant of the oral cavity
TRUE
what are acquired and therapeutic immunosuppression predisposing systemic factors of C. albicans? (3)
HIVD
Cytotoxic drugs
Corticosteroids
t/f candidiasis is an infection, but not an infectious disease
true
hwat are endocrinopathies of predisposing factors of C. albicans?
diabetes mellitus
hypoparathyroidism
hypoadrenalism
pregnancy with secondary infection of infant
t/f nutritional deficiencies, low carb diet, and antibacterial drug use are predisposing systemic factors of C albicans
FALSE! HIGH carb diet
what is the MOST COMMON ORAL CANDIDIAL INFECTION?
Denture Stomatitis (eeeeew yuck!)
smoking
salivary flow changes
sjogren syndrome
and radiotherapy are examples of __________ factors of ______ ______
predisposing
candidia albicans
t/f Hormonal changes are predisposing systemic factors of C albicans
FALSE!!!!!!! Age, YES! Hormones, NO!
what is a white pseudomembrane that can be wiped off, leaving a painful, red mucosal surface?
pseudomembranous candidiasis (remember folks, we are talking about candidiasis)
pseudomembranous candidiasis can be acute or chronic? which one?
BOTH silly!
who are the groups of people typically seen with pseudomembranous candidiasis (3)?
neonates (have thrush)
immunosuppressed pts
HIV infection pts
if your patient has a red patch on the palate or dorsum of the tongue, it is probably: _________ _________
erythematous candidiasis (atrophic-partial or complete wasting away of the body)
what has a BURNING sensation, seen in HIV disease, and after a broad-spectrum antibiotic administration?
erythematous candidiasis
all of the following statements are true about nystatin except which one?
a) nystatin is an inhibitor of ergosterol synthesis
b) the use of nystatin is limited to the tx of candidal infections of the skin, oral, and vaginal mucosa
c) liquid or lozenge formulation must contatct organism to be effective
d) it may be used as a rinse or lozenge in the oral cavity
e) sugar is added when it is used as a liquid
A! it is not an inhibitor, its a BINDER!
what is the first choice for primary line of antifungal chemotherapy (tx of oral candidiasis)?
Nystatin (Mycostatin)
t/f there are sugarless vaginal tablets for caries-prone patients
true! who needs sugar for their va-jay jay? jk
there are _______ side effects aka no drug-drug interactions with _______ chemo
minimal
antifungal
when would Clotrimazole be needed? How often?
if candidiasis is refractory (stubborn) to nystatin
5X/day
how long should Clotrimazole dissolve?
slowly, for 15-30 MINUTES!!!!!!!!!
what is not recommended for pregnant women or children younger than 3?
Clotrimazole
t/f A Clotrimazole cream may be used for denture stomatitis
true
______ will treat oral and chronic mucotaneous candidiasis
