ch 10 pharm

  1. t/f fungal infections are common after antibiotic or steroid use in an immunocompromised patient
  2. Nystatin (topical)
    Fluconazole (Diflucan)-(Systemic)
    Mycelex (clotrimazole)
    Nizoral (ketocanazole) are all what kind of agents?
    ANTIFUNGAL agents
  3. what antifungal members of the soil microbial flora have the ability to live on decaying organic matter?
    Saprophytic ("Sap" on the tree fell on the "soil")
  4. _________ are the most common organisms associated with human disease
  5. what is caused by a fungi or mold?
    mycotic infection (MY COT was covered in FUNGI and MOLD when i took it out of the garage after 15 years)
  6. what infection is opportunistic (able to spread quickly) in nature?
    mycotic infection
  7. what is the MOST common FUNGAL INFECTION seen in a dental office?
    CANDIDIA ALBICANS (thrush, candidiasis)
  8. what are three conditions that are primarily responsible for mycotic infection?
    • -HIV infection
    • -Increased use of therapeutic immunosuppression drugs for organ transplantation
    • -tx of malignant diseases
  9. what is opportunistic
    has complex pharmacologic tx
    subacute in nature
    and has a relapse tendency?
    mycotic infection
  10. what is a disease dev without overt clinical signs and symptoms?
  11. what does HSV stand for?
    herpes simplex virus
  12. what does HIVD stand for?
    human immunodeficiency viral disease
  13. a neonate is an infant younger than ___ _____ of age
    1 month
  14. what is the evolution from commensal (commen over I wont harm you) status to causing disease called?
  15. an agent that lives in an environment without causing harm is called:
    commensal agents ("commen" over don't be shy, i wont harm you)
  16. what kind of therapy inhibits ERGOSTEROL SYNTHESIS (hint: kills fungi)????
    antiFUNGAL therapy
  17. what disrupts fungal plasma by dividing to form ergosterol?
    antifungal therapy
  18. what is ergosterol necessary for?
    cellular activity (when synthesized within fungal cells from Acetyl CoA)
  19. what inhibits DNA synthesis as well as microtubule function?
    antifungal therapy
  20. how do the antifungal agents used in dentistry act, by which 2 mechanisms?
    • inhibits ergosterol synthesis
    • disrupts fungal plasma from dividing to form ergosterol
  21. which antifungal agents inhibit ergosterol synthesis? (hint: azole "you azole! you inhibited ergosterol!")
    • Clotrimazole
    • Fluconazole
    • Ketoconazole
    • Intraconazole
    • Voriconazole
  22. Lotrimin/Myclex aka _________ is the #1 drug used for ______ ________ synthesis
    • Clotrimazole
    • inhibiting ergosterol
  23. Ketoconazole = _________
    Nizoral (drug interactions)
  24. Itraconazole = _______
  25. what is the #2 drug used to inhibit ergosterol synthesis?
    Fluconazole (FLU #2)
  26. Fluconazole = ________
    Diflucan (I will DI if I get the FLU before I can get to the CAN to go #2)
  27. what is the #1 tx for candidiasis (thrush)?
    Nystatin (it will get rid of the candidiasis stat!)
  28. is there a risk for drug interaction when taking Nystatin?
    no, no there is not
  29. what are two ergosterol BINDING drugs? (2)
    • Amphotericin B
    • Nystatin
  30. t/f azoles are not entirely selective for fungal enzymes
  31. T/F there are no drug interactions for Azoles
    FALSE!!! there are MANY drug-drug interactions
  32. what is a major adverse effect of Azoles?
  33. what is the #1 Drug used to inhibit ergosterol synthesis?
    Clotrimazole (Lotrimin/Mycelex) no one will "trim" you a new "azole", you are already #1!
  34. how should Clotrimazole troche be taken? how many times/day?
    it is a lozenge that is to be dissolved in the mouth 5X/day
  35. what will interact with heart meds?
Card Set
ch 10 pharm
ch 10 pharm (love notes) including keywords