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What is the equation for GFR?
What is the equation for Creatinine Clearance?
What is the equation for
Dosing Rate
?
Time for plasma concentration of drug to be reduced by 50%
Half-life
When the ellimination of a drug = availability
Steady state
it takes 4-5 half-lives to reach this
Fraction of the drug that enters systemic circulation (
B-word
)
Bioavailabilty
Giving a big dose in the beginning to reach therepeuttic window faster
Loading dose
What is the equation for
Loading Dose
?
LD
: Loading Dose
Target Cp
: Target plasma concentration
Vss
: Volume of distribution in steady state
F
: Bioavailability
What is the equation for
Maintenance Dose
?
MD = Target C
_{p}
x CL / F
MD
: Maintenance dose
Target Cp
: Target plasma conc
CL
: clearance
F
: Bioavailability
Author
Bobopudge
ID
70677
Card Set
GE15
Description
Drug Elemination
Updated
2011-03-27T15:55:04Z
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