GE15

What is the equation for GFR?
What is the equation for Creatinine Clearance?
What is the equation for Dosing Rate?
Time for plasma concentration of drug to be reduced by 50%

Half-life
When the ellimination of a drug = availability
- Steady state
- it takes 4-5 half-lives to reach this
Fraction of the drug that enters systemic circulation (B-word)

Bioavailabilty
Giving a big dose in the beginning to reach therepeuttic window faster

Loading dose
What is the equation for Loading Dose?
- LD: Loading Dose
- Target Cp: Target plasma concentration
- Vss: Volume of distribution in steady state
- F: Bioavailability
What is the equation for Maintenance Dose?
- MD = Target C_p x CL / F
- MD: Maintenance dose
- Target Cp: Target plasma conc
- CL: clearance
- F: Bioavailability

Author

Bobopudge

70677

Card Set

GE15

Description

Drug Elemination

Updated

2011-03-27T15:55:04Z