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mishmash

  1. Brain cysts, seizures (parasite)
    Taenia solium (neurocysticercosis)
  2. Liver cysts (parasite)
    Echinococcus granulosus
  3. B12 Deficiency (parasite)
    Diphyllobothrium latum
  4. Biliary tract disease, cholangiosarcoma (parasite)
    Clonorchis sinensis
  5. Hemoptysis (parasite)
    Paragonimus westermanii
  6. Portal hypertension (parasite)
    Schistosoma mansoni
  7. Hematuria, bladder cancer (parasite)
    Schistosoma haematobium
  8. Microcytic anemia (parasite)
    Ancylostoma, Necator (hookworm)
  9. Perianal pruritis (parasite)
    pinworm: Enterobius vermicularis
  10. Typhoid fever ("tricky Ts")
    caused by Salmonella typhi
  11. Typhus ("tricky Ts")
    Caused by Rickettsia prowazekki, typhi, tsutsugamushi
  12. Chlamydia trachomatis ("tricky Ts")
    bacterial STD (and major cause of blindness -- neonatal or otherwise -- around the world)
  13. Treponema ("tricky Ts")
    spirochete, includes Pallidium (Syphillis) and Pertenue (Yaws)
  14. ("tricky Ts") Trichomonas vaginalis
    protozoan STD
  15. ("tricky Ts") Trypanosoma
    Protozoan, causes Chagas (Cruzi) or African sleeping sickness (gabiense, rhodesiense)
  16. ("tricky Ts") Toxoplasma
    Protozoan, included in TORCH infections
  17. Trichinella spiralis ("tricky Ts")
    Nematode in undercooked meat...causes periorbital edema (because likes EOMs)
  18. ("tricky Ts") Taenia solium
    tapeworm, can get larvae (causing intestinal infxn) from pork or eggs (causing neurocysticercosis) from food handlers or self if infected
  19. What is the associated tumor for this gene:

    abl
    CML
  20. What is the associated tumor for this gene:

    c-myc
    Burkitt's Lymphoma
  21. What is the associated tumor for this gene:

    bcl-2
    Follicular and undifferentiated lymphomas (inhibits apoptosis)
  22. What is the associated tumor for this gene:

    erb-B2
    • Breast
    • Ovarian
    • gastric carcinomas
  23. What is the associated tumor for this gene:

    ras
    Colon carcinoma
  24. What is the associated tumor for this gene:

    L-myc
    • Lung tumor
    • (Ls)
  25. What is the associated tumor for this gene:

    N-myc
    Neuroblastoma
  26. What is the associated tumor for this gene:

    ret
    MEN types 2,3
  27. c-kit
    Gastrointestinal stromal tumor (GIST)

    • "Do you c (see), Kit?"
    • "Do you get the GIST, Kit?"
  28. What is the associated tumor for this gene and it's chromosome:

    Rb
    13q

    Retinoblastoma
  29. What is the associated tumor for this gene and it's chromosome:

    BRCA1
    17q

    • Breast
    • Ovarian
  30. What is the associated tumor for this gene and it's chromosome:

    BRCA2
    13q

    Breast Cancer (esp. in men)
  31. What is the associated tumor for this gene and it's chromosome:

    p53
    17p

    • Most human cancers
    • Li-Fraumeni syndrome
  32. What is the associated tumor for this gene and it's chromosome:

    p16
    9p

    Melanoma
  33. What is the associated tumor for this gene and it's chromosome:

    APC
    5q

    Colorectal cancer (associated with FAP)
  34. What is the associated tumor for this gene and it's chromosome:

    WT1
    11p

    Wilms' tumor
  35. What is the associated tumor for this gene and it's chromosome:

    NF
    17q (17 letters in neurofibromatosis)

    NF -1
  36. What is the associated tumor for this gene and it's chromosome:

    NF2
    22q

    NF 2
  37. What is the associated tumor for this gene and it's chromosome:

    DPC
    18q

    • Pancreatic cancer
    • (DPC = deleted in pancreatic cancer)
  38. What is the associated tumor for this gene and it's chromosome:

    DCC
    18q

    Colon cancer

    (DCC = deleted in Colon cancer)
  39. What is this lab value a marker for:

    Prostatic acid phosphatase
    Prostatic carcinoma
  40. What is this lab value a marker for:

    CEA
    CEA - Carcinoembryonic antigen

    nonspecific but produced by 70% of colorectal and pancreatic cancers
  41. What is this lab value a marker for:

    alpha - fetoprotein
    • hepatocellular carcinoma
    • non-seminomatous germ cell tumors of the testis (yolk sac tumor)
  42. What is this lab value a marker for:

    b-hCG
    b-hCG

    • hydatidiform mole
    • Choriocarcinoma
    • Gestational trophoblastic tumors
  43. What is this lab value a marker for:

    CA-125
    • Ovarian
    • malignant epithelial tumors
  44. What is this lab value a marker for:

    S-100
    • Melanoma
    • Neural tumors
    • Astrocytomas
  45. What is this lab value a marker for:

    Alkaline phosphatase
    • Metastases to bone
    • Paget's disease of bone
    • obstructive biliary disease
  46. What is this lab value a marker for:

    Bombesin
    • Neuroblastoma
    • lung cancer
    • gastric cancer
  47. What is this lab value a marker for:

    TRAP
    "TRAP the Hairy animal"

    Hairy cell leukemia (B-cell neoplasm)
  48. What is this lab value a marker for:

    CA-19-9
    Pancreatic adenocarcinoma
  49. Which organ is affected by this toxin:

    Aflatoxin
    • (produced by Aspergillus)
    • Liver - Hepatocellular carcinoma
  50. Which organ is affected by this toxin:

    Vinyl chloride
    Liver-angiosarcoma
  51. Which organ is affected by this toxin:

    CCl4
    Liver (centrilobular necrosis, fatty change)
  52. Which organ is affected by this toxin:

    Nitrosamines
    (e.g., in smoked foods)

    • Esophagus
    • Stomach
  53. Which organ is affected by this toxin:

    Cigarette smoke
    • Larynx - squamous cell carcinoma
    • Lung - squamous and small cell
    • Kidney - renal cell carcinoma
    • Bladder - transitional cell carcinoma (also from Naphthaline/Analine dye exposure)
  54. Which organ is affected by this toxin:

    Asbestos
    Lung - mesothelioma and bronchogenic carcinoma
  55. Which organ is affected by this toxin:

    Arsenic
    • Skin - squamous cell
    • Liver - angiosarcoma
  56. Which organ is affected by this toxin:

    Naphthalene (analine) dyes
    Bladder - transitional cell (also caused by cigarette smoke)
  57. Which organ is affected by this toxin:

    Alkylating agents
    Blood (leukemia)
  58. Which (para)neoplasm can have this effect:

    Cushing's syndrome
    Small cell lung carcinoma that secretes ACTH or ACTH-like peptide
  59. Which (para)neoplasm can have this effect:

    SIADH
    ADH secreting (check this) small cell lung carcinoma and intracranial neoplasms
  60. Which (para)neoplasm can have this effect:

    Hypercalcemia
    • PTH-related peptide, TGF-B, TNF, IL-1 secretion from:
    • Squamous cell lung cancer
    • Renal cell carcinoma
    • Breast carcinoma
  61. Which (para)neoplasm can have this effect:

    polycythemia
    erythropoietin secretion from

    • Renal cell carcinoma
    • Hemangioblastoma
  62. Which (para)neoplasm can have this effect:

    Lambert-Easton syndrome
    (muscle weakness)

    secretion of antibodies against presynaptic Ca channels at neuromuscular junction by:

    • Thymoma
    • small cell lung carcinoma
  63. Which (para)neoplasm can have this effect:

    Gout
    Urate nephropathy
    Hyperuricemia due to excess nucleic acid turnover from Leukemias and lymphomas
  64. Where do you find Psammoma bodies?
    PSaMMoma:

    • -Papillary adenocarcinoma of thyroid
    • -Serous papillary cystadenocarcinoma of ovary
    • -Meningioma
    • -Malignant mesothelioma
  65. Metastasis to Brain (and mnemonic)
    (over 50% of brain tumors are from metastases)
    Lots of Bad Stuff Kills Glia

    • -Lung
    • -Breast
    • -Skin
    • -Kidney
    • -GI
  66. Metastasis to liver (and mnemonic)
    Cancer Sometimes Penetrates Benign Liver

    Colon > Stomach > Pancrease > Breast > Lung
  67. Metastasis to bone
    • Breast and Prostate (most common)
    • Thyroid
    • Testes
    • Lung
    • Kidney
Author
laurarom33
ID
70451
Card Set
mishmash
Description
assortment of facts to memorize including microbiology oncogenes
Updated

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