Type II is mediated by which Ab's?
In a Type II, what occurs when the Ab binds to the cell surface Ag?
- or stimulation of
- Opsonization and phagocytosis
How does cell destruction occur in Type II?
- Classical Complement Cascade
Indicators of RBC Destruction:
- Hemolysis observed in serum
- Low PCV
Examples of Immune Mediated Cytopenias
- Hemolytic Anemia
- Thrombocytopenia (PLT)
- Leukopenia, rare (WBC)
Two types of hemolysis that occur with cytopenias
- Extravascular Hemolysis
- Intravascular Hemolysis
With Extravascular Hemolysis, cells are tagged with ___ and removed by ____
With Intravascular Hemolysis, cells are tagged with ___ and removed by ____
- Complement lyses cells
Primary VS Secondary Immune Mediated Cytopenias
- Secondary= Drug or Infectious Agent
Infectious Agents that cause Cytopenias:
- EIAV (Ag sticks to RBC)
- Mycoplasma Canis/Felis
- Rickettsias: Erlichia/Anaplasma
- Protozoa: Babesia
- (latter alter RBC Ag)
How are Immune-Mediated Hemolytic Anemia's Dx'd?