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Type II is mediated by which Ab's?
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In a Type II, what occurs when the Ab binds to the cell surface Ag?
- Agglutination/hemolysis,
- or stimulation of
- Opsonization and phagocytosis
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How does cell destruction occur in Type II?
- Classical Complement Cascade
- ADCC
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Indicators of RBC Destruction:
- Hemolysis observed in serum
- Low PCV
- Hematuria
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Examples of Immune Mediated Cytopenias
- Hemolytic Anemia
- Thrombocytopenia (PLT)
- Leukopenia, rare (WBC)
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Two types of hemolysis that occur with cytopenias
- Extravascular Hemolysis
- Intravascular Hemolysis
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With Extravascular Hemolysis, cells are tagged with ___ and removed by ____
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With Intravascular Hemolysis, cells are tagged with ___ and removed by ____
- IgG/IgM
- Complement lyses cells
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Primary VS Secondary Immune Mediated Cytopenias
- Primary=Idiopathic
- Secondary= Drug or Infectious Agent
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Infectious Agents that cause Cytopenias:
- EIAV (Ag sticks to RBC)
- Mycoplasma Canis/Felis
- Rickettsias: Erlichia/Anaplasma
- Protozoa: Babesia
- (latter alter RBC Ag)
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How are Immune-Mediated Hemolytic Anemia's Dx'd?
Coomb's Test
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